Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity

Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity

ABSTRACT Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually causing local outbreaks and epidemics. While all three...

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Main Authors: Amy C. Sims, Alexandra Schäfer, Kenichi Okuda, Sarah R. Leist, Jacob F. Kocher, Adam S. Cockrell, Padraig E. Hawkins, Minako Furusho, Kara L. Jensen, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Kelly G. Stratton, Natalie C. Lamar, Carrie D. Niccora, Karl K. Weitz, Richard D. Smith, Thomas O. Metz, Katrina M. Waters, Richard C. Boucher, Stephanie A. Montgomery, Ralph S. Baric, Timothy P. Sheahan
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mSphere
Subjects:
coronavirus
MERS-CoV
viral pathogenesis
SARS-CoV-2
lung infection
genomics
Online Access:https://journals.asm.org/doi/10.1128/msphere.00951-24
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