Challenges and Opportunities in Managing Geriatric Depression: The Role of Personalized Medicine and Age-Appropriate Therapeutic Approaches
The global aging population has experienced rapid growth in recent decades, leading to an increased prevalence of psychiatric disorders, particularly depression, among older adults. Depression in the geriatric population is often compounded by chronic physical conditions and various psychosocial fac...
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2024-10-01
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| author | Agnieszka Jaros Filip Rybakowski Judyta Cielecka-Piontek Magdalena Paczkowska-Walendowska Bogusław Czerny Adam Kamińki Rasha Wafaie Mahmoud Elsorady Agnieszka Bienert |
| author_facet | Agnieszka Jaros Filip Rybakowski Judyta Cielecka-Piontek Magdalena Paczkowska-Walendowska Bogusław Czerny Adam Kamińki Rasha Wafaie Mahmoud Elsorady Agnieszka Bienert |
| author_sort | Agnieszka Jaros |
| collection | DOAJ |
| description | The global aging population has experienced rapid growth in recent decades, leading to an increased prevalence of psychiatric disorders, particularly depression, among older adults. Depression in the geriatric population is often compounded by chronic physical conditions and various psychosocial factors, significantly impacting their quality of life. The main question raised in this review is as follows: how can personalized medicine and age-appropriate therapeutic approaches improve the management of geriatric depression? This paper explores the epidemiology of geriatric depression, highlighting the influence of gender, race, and socioeconomic status on its prevalence. The classification and diagnosis of geriatric depressive disorders, based on ICD-11 and DSM-5 criteria, reveal the complexity of managing these conditions in older adults. Personalized medicine (PM) emerges as a promising approach, focusing on tailoring treatments to the individual’s genetic, clinical, and environmental characteristics. However, the application of PM in this demographic faces challenges, particularly in the context of pharmaceutical forms. The need for age-appropriate drug delivery systems is critical, given the prevalence of polypharmacy and issues such as dysphagia among the older patients. This study emphasizes the importance of developing patient-centric formulations to enhance the effectiveness of personalized therapy in geriatric patients. |
| format | Article |
| id | doaj-art-cfda57ed05ca4f4bb4b381001854955e |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-cfda57ed05ca4f4bb4b381001854955e2025-08-20T02:05:07ZengMDPI AGPharmaceutics1999-49232024-10-011611139710.3390/pharmaceutics16111397Challenges and Opportunities in Managing Geriatric Depression: The Role of Personalized Medicine and Age-Appropriate Therapeutic ApproachesAgnieszka Jaros0Filip Rybakowski1Judyta Cielecka-Piontek2Magdalena Paczkowska-Walendowska3Bogusław Czerny4Adam Kamińki5Rasha Wafaie Mahmoud Elsorady6Agnieszka Bienert7Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, 60-806 Poznan, PolandHead of Adult Psychiatry Clinic, Poznan University of Medical Sciences, 60-810 Poznan, PolandDepartment of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, PolandDepartment of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, PolandInstitute of Natural Fibers and Medicinal Plants National Research Institute, ul. Wojska Polskiego 71 b, 60-630 Poznan, PolandDepartment of Orthopedics nad Traumatology, Independent Public Clinical Hospital No. 1, Promeranian Medical University in Szczecin, Unii Lubleskiej 1, 71-252 Szczecin, PolandHead of Clinical Pharmacy Departments at Alexandria University Hospitals, Alexandria University, Alexandria 21523, EgyptDepartment of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, 60-806 Poznan, PolandThe global aging population has experienced rapid growth in recent decades, leading to an increased prevalence of psychiatric disorders, particularly depression, among older adults. Depression in the geriatric population is often compounded by chronic physical conditions and various psychosocial factors, significantly impacting their quality of life. The main question raised in this review is as follows: how can personalized medicine and age-appropriate therapeutic approaches improve the management of geriatric depression? This paper explores the epidemiology of geriatric depression, highlighting the influence of gender, race, and socioeconomic status on its prevalence. The classification and diagnosis of geriatric depressive disorders, based on ICD-11 and DSM-5 criteria, reveal the complexity of managing these conditions in older adults. Personalized medicine (PM) emerges as a promising approach, focusing on tailoring treatments to the individual’s genetic, clinical, and environmental characteristics. However, the application of PM in this demographic faces challenges, particularly in the context of pharmaceutical forms. The need for age-appropriate drug delivery systems is critical, given the prevalence of polypharmacy and issues such as dysphagia among the older patients. This study emphasizes the importance of developing patient-centric formulations to enhance the effectiveness of personalized therapy in geriatric patients.https://www.mdpi.com/1999-4923/16/11/1397geriatric depressionpersonalized medicinepharmaceutical forms |
| spellingShingle | Agnieszka Jaros Filip Rybakowski Judyta Cielecka-Piontek Magdalena Paczkowska-Walendowska Bogusław Czerny Adam Kamińki Rasha Wafaie Mahmoud Elsorady Agnieszka Bienert Challenges and Opportunities in Managing Geriatric Depression: The Role of Personalized Medicine and Age-Appropriate Therapeutic Approaches Pharmaceutics geriatric depression personalized medicine pharmaceutical forms |
| title | Challenges and Opportunities in Managing Geriatric Depression: The Role of Personalized Medicine and Age-Appropriate Therapeutic Approaches |
| title_full | Challenges and Opportunities in Managing Geriatric Depression: The Role of Personalized Medicine and Age-Appropriate Therapeutic Approaches |
| title_fullStr | Challenges and Opportunities in Managing Geriatric Depression: The Role of Personalized Medicine and Age-Appropriate Therapeutic Approaches |
| title_full_unstemmed | Challenges and Opportunities in Managing Geriatric Depression: The Role of Personalized Medicine and Age-Appropriate Therapeutic Approaches |
| title_short | Challenges and Opportunities in Managing Geriatric Depression: The Role of Personalized Medicine and Age-Appropriate Therapeutic Approaches |
| title_sort | challenges and opportunities in managing geriatric depression the role of personalized medicine and age appropriate therapeutic approaches |
| topic | geriatric depression personalized medicine pharmaceutical forms |
| url | https://www.mdpi.com/1999-4923/16/11/1397 |
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