α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies

α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies

Neurodegenerative diseases are characterized by protein aggregation and overlapping pathologies, challenging traditional classifications and highlighting shared underlying mechanisms. Parkinson’s disease and related synucleinopathies, including Lewy body dementia and multiple system atrophy, highlig...

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Bibliographic Details
Main Authors: Francisco J. Padilla-Godínez, Eunice Ruth Vázquez-García, María Isabel Trujillo-Villagrán, Luis O. Soto-Rojas, Marcela Palomero-Rivero, Omar Hernández-González, Francisco Pérez-Eugenio, Omar Collazo-Navarrete, Oscar Arias-Carrión, Magdalena Guerra-Crespo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
tau
synucleinopathy
tauopathy
proteinopathy
Lewy bodies
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1570553/full
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