Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primates
In silico approach to the evolution of ionotropic glutamate receptor gene family in four primate species. Man as a species has a brainunique in analysis capabilities due to its structure and organizational patterns that are presumably the basis of intelligence and the ability tomanipulate the enviro...
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Pontificia Universidad Javeriana
2010-12-01
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| Series: | Universitas Scientiarum |
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| Online Access: | http://revistas.javeriana.edu.co/index.php/scientarium/article/view/1355/821 |
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| author | Nury E. Vargas-Alejo Edgar A. Reyes-Montaño Leonardo Lareo |
| author_facet | Nury E. Vargas-Alejo Edgar A. Reyes-Montaño Leonardo Lareo |
| author_sort | Nury E. Vargas-Alejo |
| collection | DOAJ |
| description | In silico approach to the evolution of ionotropic glutamate receptor gene family in four primate species. Man as a species has a brainunique in analysis capabilities due to its structure and organizational patterns that are presumably the basis of intelligence and the ability tomanipulate the environment. Additionally, the development and evolution of the brain respond underlying genetic processes. Objective. Topresent an approach to the evolutionary process of the iGluR with the maximum likelihood (ML) and Bayesian (By) phylogenetic analysismethods. Materials and methods. we used in silico methods to propose a model of molecular evolution and to do a qualitative recognitionof synteny blocks for these genes in different species of primates (chimpanzee, orangutan, rhesus monkey and man). Results. Glutamateis the main neurotransmitter and plays an important role in neuronal plasticity and neurotoxicity. Neurotransmission via glutamate ismediated by ionotropic glutamate receptors (iGluR) NMDA type and non-NMDA type (AMPA and KA). For every phylogeneticinference, we confirmed that the iGluRs of mammals could have evolved from a primitive signaling mechanism, thus explaining similarclusters between some species of primates and rodents. Conclusion. The NR-2 sequences have been exposed to a purifying selection, andthe neutral level of divergence is faster in primates than in rodents, however further studies are needed to confirm these theories of evolution. |
| format | Article |
| id | doaj-art-cfca7d238dab45809eacadfaeef36694 |
| institution | OA Journals |
| issn | 0122-7483 2027-1352 |
| language | English |
| publishDate | 2010-12-01 |
| publisher | Pontificia Universidad Javeriana |
| record_format | Article |
| series | Universitas Scientiarum |
| spelling | doaj-art-cfca7d238dab45809eacadfaeef366942025-08-20T02:20:06ZengPontificia Universidad JaverianaUniversitas Scientiarum0122-74832027-13522010-12-01153194205Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primatesNury E. Vargas-AlejoEdgar A. Reyes-MontañoLeonardo LareoIn silico approach to the evolution of ionotropic glutamate receptor gene family in four primate species. Man as a species has a brainunique in analysis capabilities due to its structure and organizational patterns that are presumably the basis of intelligence and the ability tomanipulate the environment. Additionally, the development and evolution of the brain respond underlying genetic processes. Objective. Topresent an approach to the evolutionary process of the iGluR with the maximum likelihood (ML) and Bayesian (By) phylogenetic analysismethods. Materials and methods. we used in silico methods to propose a model of molecular evolution and to do a qualitative recognitionof synteny blocks for these genes in different species of primates (chimpanzee, orangutan, rhesus monkey and man). Results. Glutamateis the main neurotransmitter and plays an important role in neuronal plasticity and neurotoxicity. Neurotransmission via glutamate ismediated by ionotropic glutamate receptors (iGluR) NMDA type and non-NMDA type (AMPA and KA). For every phylogeneticinference, we confirmed that the iGluRs of mammals could have evolved from a primitive signaling mechanism, thus explaining similarclusters between some species of primates and rodents. Conclusion. The NR-2 sequences have been exposed to a purifying selection, andthe neutral level of divergence is faster in primates than in rodents, however further studies are needed to confirm these theories of evolution.http://revistas.javeriana.edu.co/index.php/scientarium/article/view/1355/821evolution in gene familiesphylogenetic inference of ML and ByiGluRAMPAKANMDA |
| spellingShingle | Nury E. Vargas-Alejo Edgar A. Reyes-Montaño Leonardo Lareo Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primates Universitas Scientiarum evolution in gene families phylogenetic inference of ML and By iGluR AMPA KA NMDA |
| title | Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primates |
| title_full | Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primates |
| title_fullStr | Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primates |
| title_full_unstemmed | Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primates |
| title_short | Aproximación in silico a la evolución de la familia de genes que conforman el receptor ionotrópico de glutamato en cuatro especies de primates |
| title_sort | aproximacion in silico a la evolucion de la familia de genes que conforman el receptor ionotropico de glutamato en cuatro especies de primates |
| topic | evolution in gene families phylogenetic inference of ML and By iGluR AMPA KA NMDA |
| url | http://revistas.javeriana.edu.co/index.php/scientarium/article/view/1355/821 |
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