Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration

Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration

Abstract Background Dysregulation of maternal glucose homeostasis has been related to an increased risk of morbidity and mortality in mothers and fetuses, yet the mechanism remains unclear. This study investigated the association between maternal glycemic levels and placental epigenetic age accelera...

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Main Authors: Tesfa Dejenie Habtewold, Prabhavi Wijesiriwardhana, Richard J. Biedrzycki, Cuilin Zhang, Katherine L. Grantz, Jagteshwar Grewal, Fasil Tekola-Ayele
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Clinical Epigenetics
Subjects:
Placental age acceleration
Placental aging
Hyperglycemia
Glycemic biomarkers
Pregnancy
Longitudinal modeling
Online Access:https://doi.org/10.1186/s13148-025-01825-z
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