External ear malformations and cardiac and renal anomalies: A systematic review and meta-analysis.
<h4>Context</h4>External Ear Malformations (EEM) continue to be a common malformation seen in the pediatric patient population. This study aims to further elucidate the correlation between EEM and cardiac and renal anomalies.<h4>Objective</h4>A systematic review and meta-anal...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0309692 |
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| author | Arman Ghafari Leonardo Alaniz Cindy Vu Alejandra Ibarra Medha Vallurupalli Sierra Willens Justin Cordero Miles J Pfaff |
| author_facet | Arman Ghafari Leonardo Alaniz Cindy Vu Alejandra Ibarra Medha Vallurupalli Sierra Willens Justin Cordero Miles J Pfaff |
| author_sort | Arman Ghafari |
| collection | DOAJ |
| description | <h4>Context</h4>External Ear Malformations (EEM) continue to be a common malformation seen in the pediatric patient population. This study aims to further elucidate the correlation between EEM and cardiac and renal anomalies.<h4>Objective</h4>A systematic review and meta-analysis to study the incidence of cardiac and renal anomalies associated with syndromic and isolated (EEM).<h4>Data sources</h4>The literature search spanned multiple databases, including Google Scholar, PubMed, Scopus, Web of Science, and MEDLINE.<h4>Study selection</h4>Studies must be focused on EEM and cardiac and/or renal anomalies. Only articles written in English were included.<h4>Data extraction</h4>General study characteristics, number of EEM patients, number of cardiac and renal anomalies and whether cases were syndromic were extracted from the studies.<h4>Results</h4>Of 1,058 initial studies, 33 were included for meta-analyses. Mean JBI score for all included studies was 92.06%, indicating acceptable study quality. Interrater reliability was high, with a Cohen kappa score for all studies of 0.94. The resulting pooled prevalence of cardiac abnormalities was 20% [95% CI:13-28%], while renal abnormalities were 13% [95% CI: 7-20%]. The most common anomalies were VSD (3.725%) and renal agenesis (2.04%). The presence of syndrome data across studies was not a significant modifier of prevalence rates.<h4>Limitations</h4>Primary limitation is due to heterogeneity in individual study methodology and reporting standards.<h4>Conclusions</h4>These results highlight a higher prevalence of cardiac-related conditions than renal anomalies in patients with both syndromic and non-syndromic EEM in the included studies, underscoring the need for thorough clinical evaluations. |
| format | Article |
| id | doaj-art-cfc51c3f56a64e93828f7e410aec3b3f |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-cfc51c3f56a64e93828f7e410aec3b3f2025-08-20T03:34:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01199e030969210.1371/journal.pone.0309692External ear malformations and cardiac and renal anomalies: A systematic review and meta-analysis.Arman GhafariLeonardo AlanizCindy VuAlejandra IbarraMedha VallurupalliSierra WillensJustin CorderoMiles J Pfaff<h4>Context</h4>External Ear Malformations (EEM) continue to be a common malformation seen in the pediatric patient population. This study aims to further elucidate the correlation between EEM and cardiac and renal anomalies.<h4>Objective</h4>A systematic review and meta-analysis to study the incidence of cardiac and renal anomalies associated with syndromic and isolated (EEM).<h4>Data sources</h4>The literature search spanned multiple databases, including Google Scholar, PubMed, Scopus, Web of Science, and MEDLINE.<h4>Study selection</h4>Studies must be focused on EEM and cardiac and/or renal anomalies. Only articles written in English were included.<h4>Data extraction</h4>General study characteristics, number of EEM patients, number of cardiac and renal anomalies and whether cases were syndromic were extracted from the studies.<h4>Results</h4>Of 1,058 initial studies, 33 were included for meta-analyses. Mean JBI score for all included studies was 92.06%, indicating acceptable study quality. Interrater reliability was high, with a Cohen kappa score for all studies of 0.94. The resulting pooled prevalence of cardiac abnormalities was 20% [95% CI:13-28%], while renal abnormalities were 13% [95% CI: 7-20%]. The most common anomalies were VSD (3.725%) and renal agenesis (2.04%). The presence of syndrome data across studies was not a significant modifier of prevalence rates.<h4>Limitations</h4>Primary limitation is due to heterogeneity in individual study methodology and reporting standards.<h4>Conclusions</h4>These results highlight a higher prevalence of cardiac-related conditions than renal anomalies in patients with both syndromic and non-syndromic EEM in the included studies, underscoring the need for thorough clinical evaluations.https://doi.org/10.1371/journal.pone.0309692 |
| spellingShingle | Arman Ghafari Leonardo Alaniz Cindy Vu Alejandra Ibarra Medha Vallurupalli Sierra Willens Justin Cordero Miles J Pfaff External ear malformations and cardiac and renal anomalies: A systematic review and meta-analysis. PLoS ONE |
| title | External ear malformations and cardiac and renal anomalies: A systematic review and meta-analysis. |
| title_full | External ear malformations and cardiac and renal anomalies: A systematic review and meta-analysis. |
| title_fullStr | External ear malformations and cardiac and renal anomalies: A systematic review and meta-analysis. |
| title_full_unstemmed | External ear malformations and cardiac and renal anomalies: A systematic review and meta-analysis. |
| title_short | External ear malformations and cardiac and renal anomalies: A systematic review and meta-analysis. |
| title_sort | external ear malformations and cardiac and renal anomalies a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0309692 |
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