Overview of homocysteine and its role in disease processes
Homocysteine is a sulfur-containing amino acid formed from the essential amino acid methionine. This metabolism cycle requires vitamin-derived cofactors, pyridoxine for transsulfuration and both folate and cobalamin [1]. In a normal diet there is conservation of the carbon skeleton, and about 50% o...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nicolaus Copernicus University in Toruń
2025-05-01
|
| Series: | Quality in Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/QS/article/view/60254 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850190986272047104 |
|---|---|
| author | Aleksandra Kędzia Michał Bolek Bartosz Jagieła Monika Fidyk Dominika Musialska Magda Minkiewicz |
| author_facet | Aleksandra Kędzia Michał Bolek Bartosz Jagieła Monika Fidyk Dominika Musialska Magda Minkiewicz |
| author_sort | Aleksandra Kędzia |
| collection | DOAJ |
| description |
Homocysteine is a sulfur-containing amino acid formed from the essential amino acid methionine. This metabolism cycle requires vitamin-derived cofactors, pyridoxine for transsulfuration and both folate and cobalamin [1]. In a normal diet there is conservation of the carbon skeleton, and about 50% of the homocysteine formed is remethylated to methionine via steps that require folic acid and vitamin B12. A deficiency of any of these three vitamins leads to modest homocysteine elevation. Why does hyperhomocysteinemia play a vital role in medical practice? It is established that homocysteine elevation is associated with different complications, mainly increased cardiovascular risk [2]. Hyperhomocysteinemia and homocystinuria is connected with occlusive artery disease, especially in the brain, the heart, and the kidney, in addition to venous thrombosis. However the increased level of homocysteine has also an impact on other systems and is connected with osteoporosis, depression, Alzheimer's disease, pregnancy problems, and others. Elevated homocysteine levels occur in both the adult and child population [3].
This review article will address the importance of homocysteine in nervous and cardiovascular systems but also indicate some controversial theses and reasons to further investigation.
|
| format | Article |
| id | doaj-art-cfc500d5e7544be9a436d4adb2f1ee8a |
| institution | OA Journals |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-cfc500d5e7544be9a436d4adb2f1ee8a2025-08-20T02:15:06ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-05-014110.12775/QS.2025.41.60254Overview of homocysteine and its role in disease processesAleksandra Kędzia0https://orcid.org/0009-0001-4130-2983Michał Bolek1https://orcid.org/0009-0004-7991-3212Bartosz Jagieła2https://orcid.org/0009-0006-5592-1511Monika Fidyk3https://orcid.org/0009-0006-8664-8132Dominika Musialska4https://orcid.org/0009-0006-5886-5543Magda Minkiewicz5https://orcid.org/0009-0005-7492-8033DCOPiH (Lower Silesian Oncology Center in Wrocław) Ludwika Hirszfelda Square 12, 53-413 Wrocław, Poland 4th Military Clinical Hospital in Wroclaw Weigla 5, 53-114 Wroclaw, Poland University Clinical Hospital of Jan Mikulicz-Radecki in Wroclaw Borowska 213, 50-556 Wroclaw, Poland 4th Military Clinical Hospital in Wroclaw, Weigla 5, 53-114 Wroclaw, Poland 4th Military Clinical Hospital SP ZOZ, Weigla 5, 53-114 Wrocław, Poland University Clinical Hospital of Jan Mikulicz-Radecki in Wroclaw Borowska 213, 50-556 Wroclaw, Poland Homocysteine is a sulfur-containing amino acid formed from the essential amino acid methionine. This metabolism cycle requires vitamin-derived cofactors, pyridoxine for transsulfuration and both folate and cobalamin [1]. In a normal diet there is conservation of the carbon skeleton, and about 50% of the homocysteine formed is remethylated to methionine via steps that require folic acid and vitamin B12. A deficiency of any of these three vitamins leads to modest homocysteine elevation. Why does hyperhomocysteinemia play a vital role in medical practice? It is established that homocysteine elevation is associated with different complications, mainly increased cardiovascular risk [2]. Hyperhomocysteinemia and homocystinuria is connected with occlusive artery disease, especially in the brain, the heart, and the kidney, in addition to venous thrombosis. However the increased level of homocysteine has also an impact on other systems and is connected with osteoporosis, depression, Alzheimer's disease, pregnancy problems, and others. Elevated homocysteine levels occur in both the adult and child population [3]. This review article will address the importance of homocysteine in nervous and cardiovascular systems but also indicate some controversial theses and reasons to further investigation. https://apcz.umk.pl/QS/article/view/60254Homocysteinecardiovascular diseaseshomocysteine metabolismhiperhomocysteinemiaNeurodegenerationCognitive diseases |
| spellingShingle | Aleksandra Kędzia Michał Bolek Bartosz Jagieła Monika Fidyk Dominika Musialska Magda Minkiewicz Overview of homocysteine and its role in disease processes Quality in Sport Homocysteine cardiovascular diseases homocysteine metabolism hiperhomocysteinemia Neurodegeneration Cognitive diseases |
| title | Overview of homocysteine and its role in disease processes |
| title_full | Overview of homocysteine and its role in disease processes |
| title_fullStr | Overview of homocysteine and its role in disease processes |
| title_full_unstemmed | Overview of homocysteine and its role in disease processes |
| title_short | Overview of homocysteine and its role in disease processes |
| title_sort | overview of homocysteine and its role in disease processes |
| topic | Homocysteine cardiovascular diseases homocysteine metabolism hiperhomocysteinemia Neurodegeneration Cognitive diseases |
| url | https://apcz.umk.pl/QS/article/view/60254 |
| work_keys_str_mv | AT aleksandrakedzia overviewofhomocysteineanditsroleindiseaseprocesses AT michałbolek overviewofhomocysteineanditsroleindiseaseprocesses AT bartoszjagieła overviewofhomocysteineanditsroleindiseaseprocesses AT monikafidyk overviewofhomocysteineanditsroleindiseaseprocesses AT dominikamusialska overviewofhomocysteineanditsroleindiseaseprocesses AT magdaminkiewicz overviewofhomocysteineanditsroleindiseaseprocesses |