Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin
Background: Previous studies have demonstrated perfluoroalkyl and polyfluoroalkyl substances (PFAS) impact renal function, with albumin playing dominant role in their transport and accumulation. However, the mediating role of albumin in PFAS-induced renal impairment and the identification of sensiti...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016750 |
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| author | Hua Fang Huajing Chang Danjing Chen Wenxin Qiu Jiangwang Fang Yunli Wu Xian-E. Peng |
| author_facet | Hua Fang Huajing Chang Danjing Chen Wenxin Qiu Jiangwang Fang Yunli Wu Xian-E. Peng |
| author_sort | Hua Fang |
| collection | DOAJ |
| description | Background: Previous studies have demonstrated perfluoroalkyl and polyfluoroalkyl substances (PFAS) impact renal function, with albumin playing dominant role in their transport and accumulation. However, the mediating role of albumin in PFAS-induced renal impairment and the identification of sensitive populations remain uninvestigated. Methods: This study included 9328 individuals from NHANES 1999–2018 with data on serum PFAS, creatinine, albumin, and covariates. The estimated glomerular filtration rate (eGFR) was calculated using standardized creatinine. Associations between perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA) with eGFR and the risk of decreased renal function (eGFR < 90 vs. eGFR ≥ 90) using linear and logistic regression, weighted quantile sum (WQS) regression, Bayesian kernel machine regression (BKMR), and restricted cubic spline (RCS) analyses. Subgroup analyses identified sensitive populations. Mediation analysis was performed to examine the mediating role of albumin. Comparative toxicology databases identified relevant genes for mechanistic exploration. Results: Ln-transformed PFOA (β = −1.91, 95 % CI: −2.82 to −1), PFOS (β = −1.48, 95 % CI: −2.19 to −0.78) and PFHxS (β = −0.94, 95 % CI: −1.65 to −0.23) were negatively correlated with eGFR. PFOA (aOR = 1.21, 95 % CI: 1.1–1.32), PFOS (aOR = 1.2, 95 % CI: 1.12–1.29), and PFHxS (aOR = 1.13, 95 % CI: 1.05–1.21) were positively correlated with the risk of decreased renal function. Subgroup analyses indicated that individuals ≤ 45 years, females and other races were more sensitive. Albumin mediated 18.2 %, 16.4 %, 29.8 %, and 18.7 % of the negative effects of PFOA, PFOS, PFHxS, and PFNA on eGFR, respectively. Functional enrichment analysis suggested PFAS impair renal function by affecting lipid metabolism and increasing oxidative stress. Conclusions: PFAS exposure is negatively associated with eGFR and positively associated with the risk of decreased renal function, with albumin playing a partial mediating role. |
| format | Article |
| id | doaj-art-cfc2042623fe4403bcde54419003c5cf |
| institution | Kabale University |
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| publishDate | 2025-01-01 |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-cfc2042623fe4403bcde54419003c5cf2025-02-12T05:29:56ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117599Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albuminHua Fang0Huajing Chang1Danjing Chen2Wenxin Qiu3Jiangwang Fang4Yunli Wu5Xian-E. Peng6Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Xuefu North Road 1St, Shangjie Town, Minhou Country, Fuzhou, Fujian 350108, ChinaDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Xuefu North Road 1St, Shangjie Town, Minhou Country, Fuzhou, Fujian 350108, ChinaDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Xuefu North Road 1St, Shangjie Town, Minhou Country, Fuzhou, Fujian 350108, ChinaDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Xuefu North Road 1St, Shangjie Town, Minhou Country, Fuzhou, Fujian 350108, ChinaDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Xuefu North Road 1St, Shangjie Town, Minhou Country, Fuzhou, Fujian 350108, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, China; Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Xuefu North Road 1St, Shangjie Town, Minhou Country, Fuzhou, Fujian 350108, China; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, China; Corresponding author at: Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, China.Background: Previous studies have demonstrated perfluoroalkyl and polyfluoroalkyl substances (PFAS) impact renal function, with albumin playing dominant role in their transport and accumulation. However, the mediating role of albumin in PFAS-induced renal impairment and the identification of sensitive populations remain uninvestigated. Methods: This study included 9328 individuals from NHANES 1999–2018 with data on serum PFAS, creatinine, albumin, and covariates. The estimated glomerular filtration rate (eGFR) was calculated using standardized creatinine. Associations between perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA) with eGFR and the risk of decreased renal function (eGFR < 90 vs. eGFR ≥ 90) using linear and logistic regression, weighted quantile sum (WQS) regression, Bayesian kernel machine regression (BKMR), and restricted cubic spline (RCS) analyses. Subgroup analyses identified sensitive populations. Mediation analysis was performed to examine the mediating role of albumin. Comparative toxicology databases identified relevant genes for mechanistic exploration. Results: Ln-transformed PFOA (β = −1.91, 95 % CI: −2.82 to −1), PFOS (β = −1.48, 95 % CI: −2.19 to −0.78) and PFHxS (β = −0.94, 95 % CI: −1.65 to −0.23) were negatively correlated with eGFR. PFOA (aOR = 1.21, 95 % CI: 1.1–1.32), PFOS (aOR = 1.2, 95 % CI: 1.12–1.29), and PFHxS (aOR = 1.13, 95 % CI: 1.05–1.21) were positively correlated with the risk of decreased renal function. Subgroup analyses indicated that individuals ≤ 45 years, females and other races were more sensitive. Albumin mediated 18.2 %, 16.4 %, 29.8 %, and 18.7 % of the negative effects of PFOA, PFOS, PFHxS, and PFNA on eGFR, respectively. Functional enrichment analysis suggested PFAS impair renal function by affecting lipid metabolism and increasing oxidative stress. Conclusions: PFAS exposure is negatively associated with eGFR and positively associated with the risk of decreased renal function, with albumin playing a partial mediating role.http://www.sciencedirect.com/science/article/pii/S0147651324016750Perfluoroalkyl and polyfluoroalkyl substances (PFAS)Glomerular filtration rateMixed effectAlbumin |
| spellingShingle | Hua Fang Huajing Chang Danjing Chen Wenxin Qiu Jiangwang Fang Yunli Wu Xian-E. Peng Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin Ecotoxicology and Environmental Safety Perfluoroalkyl and polyfluoroalkyl substances (PFAS) Glomerular filtration rate Mixed effect Albumin |
| title | Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin |
| title_full | Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin |
| title_fullStr | Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin |
| title_full_unstemmed | Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin |
| title_short | Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin |
| title_sort | association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate mediating role of serum albumin |
| topic | Perfluoroalkyl and polyfluoroalkyl substances (PFAS) Glomerular filtration rate Mixed effect Albumin |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016750 |
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