Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experience
Abstract Introduction Radiation induced urethral stenosis disease represents a complex subset of patients with higher rates of recurrence after treatment. Optilume®, a Paclitaxel drug-coated balloon, has been utilized in anterior urethral strictures with promising results. Although urethroplasty is...
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BMC
2025-07-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-025-01829-0 |
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| author | Brian Ceballos Eshan G. Joshi Kayla Graham Luke Shumaker Katherine Englander Victoria Stowasser J. Patrick Selph Lucas Wiegand Kevin Heinsimer Maxim McKibben Maia VanDyke Steven Hudak Allen Morey Adam Baumgarten |
| author_facet | Brian Ceballos Eshan G. Joshi Kayla Graham Luke Shumaker Katherine Englander Victoria Stowasser J. Patrick Selph Lucas Wiegand Kevin Heinsimer Maxim McKibben Maia VanDyke Steven Hudak Allen Morey Adam Baumgarten |
| author_sort | Brian Ceballos |
| collection | DOAJ |
| description | Abstract Introduction Radiation induced urethral stenosis disease represents a complex subset of patients with higher rates of recurrence after treatment. Optilume®, a Paclitaxel drug-coated balloon, has been utilized in anterior urethral strictures with promising results. Although urethroplasty is traditionally regarded as the gold standard for treating radiation-induced posterior urethral stenosis, it can be an invasive and challenging procedure with potential side effects. We aim to evaluate the efficacy of the Optilume® drug-coated balloon as a minimally invasive treatment option for radiation-induced posterior urethral stenosis. Methods A retrospective, multi-institutional review was conducted on male patients who underwent Optilume® drug-coated balloon dilation from January 1, 2022, to November 1, 2023. The study involved five surgeons across four institutions. Patients were investigated based on their history of radiation-induced posterior urethral stenosis, and comparisons were made regarding demographics, characteristics of urethral stenosis, and outcomes, including surgical success and complications. Results Among the 56 patients with radiation-induced posterior urethral stenosis evaluated across all four institutions, 37 men had at least 90-day follow-up data. Of these 37 patients, 30 (81.1%) were deemed successful, defined as being free from repeat intervention. Although 6 patients (10.7%) experienced complications, none were greater than Clavien IIIb, with the most common complication being acute urinary retention. Conclusion Although radiation-induced urethral stenosis is typically associated with high rates of recurrence following conservative treatment, Optilume® drug-coated balloon represents an alternative endoscopic treatment option with encouraging short-term results. |
| format | Article |
| id | doaj-art-cfbdaa03e1eb4a6cb19497ee91ea342b |
| institution | Kabale University |
| issn | 1471-2490 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj-art-cfbdaa03e1eb4a6cb19497ee91ea342b2025-08-20T03:46:15ZengBMCBMC Urology1471-24902025-07-012511410.1186/s12894-025-01829-0Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experienceBrian Ceballos0Eshan G. Joshi1Kayla Graham2Luke Shumaker3Katherine Englander4Victoria Stowasser5J. Patrick Selph6Lucas Wiegand7Kevin Heinsimer8Maxim McKibben9Maia VanDyke10Steven Hudak11Allen Morey12Adam Baumgarten13Department of Urology, University of Alabama at BirminghamDepartment of Urology, University of Texas Southwestern Medical CenterDepartment of Urology, Atrium HealthDepartment of Urology, University of Alabama at BirminghamDepartment of Urology, University of South FloridaDepartment of Urology, University of Alabama at BirminghamUrology Associates of NashvilleDepartment of Urology, University of South FloridaDepartment of Urology, University of South FloridaDepartment of Urology, Atrium HealthDepartment of Urology, University of Texas Southwestern Medical CenterDepartment of Urology, University of Texas Southwestern Medical CenterUrology Clinics of North TexasDepartment of Urology, University of Alabama at BirminghamAbstract Introduction Radiation induced urethral stenosis disease represents a complex subset of patients with higher rates of recurrence after treatment. Optilume®, a Paclitaxel drug-coated balloon, has been utilized in anterior urethral strictures with promising results. Although urethroplasty is traditionally regarded as the gold standard for treating radiation-induced posterior urethral stenosis, it can be an invasive and challenging procedure with potential side effects. We aim to evaluate the efficacy of the Optilume® drug-coated balloon as a minimally invasive treatment option for radiation-induced posterior urethral stenosis. Methods A retrospective, multi-institutional review was conducted on male patients who underwent Optilume® drug-coated balloon dilation from January 1, 2022, to November 1, 2023. The study involved five surgeons across four institutions. Patients were investigated based on their history of radiation-induced posterior urethral stenosis, and comparisons were made regarding demographics, characteristics of urethral stenosis, and outcomes, including surgical success and complications. Results Among the 56 patients with radiation-induced posterior urethral stenosis evaluated across all four institutions, 37 men had at least 90-day follow-up data. Of these 37 patients, 30 (81.1%) were deemed successful, defined as being free from repeat intervention. Although 6 patients (10.7%) experienced complications, none were greater than Clavien IIIb, with the most common complication being acute urinary retention. Conclusion Although radiation-induced urethral stenosis is typically associated with high rates of recurrence following conservative treatment, Optilume® drug-coated balloon represents an alternative endoscopic treatment option with encouraging short-term results.https://doi.org/10.1186/s12894-025-01829-0Urethral strictureRadiationOptilumeBalloon dilation |
| spellingShingle | Brian Ceballos Eshan G. Joshi Kayla Graham Luke Shumaker Katherine Englander Victoria Stowasser J. Patrick Selph Lucas Wiegand Kevin Heinsimer Maxim McKibben Maia VanDyke Steven Hudak Allen Morey Adam Baumgarten Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experience BMC Urology Urethral stricture Radiation Optilume Balloon dilation |
| title | Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experience |
| title_full | Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experience |
| title_fullStr | Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experience |
| title_full_unstemmed | Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experience |
| title_short | Optilume balloon dilation for radiation induced posterior urethral stenosis: a multi-institutional experience |
| title_sort | optilume balloon dilation for radiation induced posterior urethral stenosis a multi institutional experience |
| topic | Urethral stricture Radiation Optilume Balloon dilation |
| url | https://doi.org/10.1186/s12894-025-01829-0 |
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