Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan
Abstract Background While previous literature suggests that multimorbidity is linked to a higher risk of mortality, evidence is scarce among individuals in middle adulthood. We aimed to examine the association between physical multimorbidity and all-cause mortality among individuals aged 40–64 years...
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BMC
2025-01-01
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| Online Access: | https://doi.org/10.1186/s12889-024-21166-5 |
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| author | Yosuke Inoue Seitaro Suzuki Norie Sawada Naho Morisaki Zui Narita Taiki Yamaji Yoshihiro Kokubo Takehiko Doi Yukiko Nishita Motoki Iwasaki Manami Inoue Tetsuya Mizoue |
| author_facet | Yosuke Inoue Seitaro Suzuki Norie Sawada Naho Morisaki Zui Narita Taiki Yamaji Yoshihiro Kokubo Takehiko Doi Yukiko Nishita Motoki Iwasaki Manami Inoue Tetsuya Mizoue |
| author_sort | Yosuke Inoue |
| collection | DOAJ |
| description | Abstract Background While previous literature suggests that multimorbidity is linked to a higher risk of mortality, evidence is scarce among individuals in middle adulthood. We aimed to examine the association between physical multimorbidity and all-cause mortality among individuals aged 40–64 years at baseline in Japan. Methods Data were obtained from two cohort studies, the Japan Public Health Center-based Prospective Study (JPHC) and the Japan Epidemiology Collaboration on Occupational Health Study (J-ECOH). The study participants were 144,774 individuals aged 40–64 years at baseline who were followed up for a maximum of 29 and 10 years in the JPHC and J-ECOH, respectively. Multimorbidity was defined as the presence of ≥ 2 of 10 morbidities or conditions based on self-reported information. A Cox proportional hazards model was used to examine the association in relation to all-cause mortality. We calculated pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI) using a random-effects meta-analysis model. Cause-specific analysis was performed using the JPHC dataset, which provided a sufficient number of events for mortality due to physical disorders, mental disorders/suicide, and unintentional injuries. Results During a follow-up of 2,304,375 person-years in the JPHC and 311,637 person-years in the J-ECOH, 23,611 and 275 deaths were recorded, respectively. Participants with vs. without physical multimorbidity at baseline were more likely to die prematurely in both cohorts with a pooled HR of 1.61 (95%CI = 1.29–2.01). Cause-specific analyses among the JPHC participants revealed that physical multimorbidity at baseline was linked with mortality due to physical disorders, mortality due to mental disorders/suicide, and mortality due to unintentional injuries. Conclusions Physical multimorbidity in middle adulthood is associated with an increased risk of all-cause mortality in Japan. |
| format | Article |
| id | doaj-art-cfb9a9fd97bf409694cd5a289508e906 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Public Health |
| spelling | doaj-art-cfb9a9fd97bf409694cd5a289508e9062025-01-12T12:42:47ZengBMCBMC Public Health1471-24582025-01-0125111010.1186/s12889-024-21166-5Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in JapanYosuke Inoue0Seitaro Suzuki1Norie Sawada2Naho Morisaki3Zui Narita4Taiki Yamaji5Yoshihiro Kokubo6Takehiko Doi7Yukiko Nishita8Motoki Iwasaki9Manami Inoue10Tetsuya Mizoue11Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and MedicineDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer CenterDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer CenterDepartment of Social Medicine, Research Institute, National Center for Child Health and DevelopmentDepartment of Behavioral Medicine, National Institute of Mental Health, National Center for Neurology and PsychiatryDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer CenterDepartment of Preventive Cardiology, National Cerebral and Cardiovascular CenterDepartment of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and GerontologyDepartment of Epidemiology of Aging, Center for Gerontology and Social Science, National Center for Geriatrics and GerontologyDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer CenterDivision of Prevention, National Cancer Center Institute for Cancer Control, National Cancer CenterDepartment of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and MedicineAbstract Background While previous literature suggests that multimorbidity is linked to a higher risk of mortality, evidence is scarce among individuals in middle adulthood. We aimed to examine the association between physical multimorbidity and all-cause mortality among individuals aged 40–64 years at baseline in Japan. Methods Data were obtained from two cohort studies, the Japan Public Health Center-based Prospective Study (JPHC) and the Japan Epidemiology Collaboration on Occupational Health Study (J-ECOH). The study participants were 144,774 individuals aged 40–64 years at baseline who were followed up for a maximum of 29 and 10 years in the JPHC and J-ECOH, respectively. Multimorbidity was defined as the presence of ≥ 2 of 10 morbidities or conditions based on self-reported information. A Cox proportional hazards model was used to examine the association in relation to all-cause mortality. We calculated pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI) using a random-effects meta-analysis model. Cause-specific analysis was performed using the JPHC dataset, which provided a sufficient number of events for mortality due to physical disorders, mental disorders/suicide, and unintentional injuries. Results During a follow-up of 2,304,375 person-years in the JPHC and 311,637 person-years in the J-ECOH, 23,611 and 275 deaths were recorded, respectively. Participants with vs. without physical multimorbidity at baseline were more likely to die prematurely in both cohorts with a pooled HR of 1.61 (95%CI = 1.29–2.01). Cause-specific analyses among the JPHC participants revealed that physical multimorbidity at baseline was linked with mortality due to physical disorders, mortality due to mental disorders/suicide, and mortality due to unintentional injuries. Conclusions Physical multimorbidity in middle adulthood is associated with an increased risk of all-cause mortality in Japan.https://doi.org/10.1186/s12889-024-21166-5MultimorbidityProspective studiesCause of deathJapan |
| spellingShingle | Yosuke Inoue Seitaro Suzuki Norie Sawada Naho Morisaki Zui Narita Taiki Yamaji Yoshihiro Kokubo Takehiko Doi Yukiko Nishita Motoki Iwasaki Manami Inoue Tetsuya Mizoue Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan BMC Public Health Multimorbidity Prospective studies Cause of death Japan |
| title | Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan |
| title_full | Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan |
| title_fullStr | Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan |
| title_full_unstemmed | Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan |
| title_short | Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan |
| title_sort | association between physical multimorbidity in middle adulthood and mortality findings from two large cohort studies in japan |
| topic | Multimorbidity Prospective studies Cause of death Japan |
| url | https://doi.org/10.1186/s12889-024-21166-5 |
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