Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection.
<h4>Objective</h4>Single voxel proton magnetic resonance spectroscopy (MRS) can be used to monitor changes in brain inflammation and neuronal integrity associated with HIV infection and its treatments. We used MRS to measure brain changes during the first weeks following HIV infection an...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049272&type=printable |
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| author | Napapon Sailasuta William Ross Jintanat Ananworanich Thep Chalermchai Victor DeGruttola Sukalaya Lerdlum Mantana Pothisri Edgar Busovaca Silvia Ratto-Kim Linda Jagodzinski Serena Spudich Nelson Michael Jerome H Kim Victor Valcour RV254/SEARCH 010 protocol teams |
| author_facet | Napapon Sailasuta William Ross Jintanat Ananworanich Thep Chalermchai Victor DeGruttola Sukalaya Lerdlum Mantana Pothisri Edgar Busovaca Silvia Ratto-Kim Linda Jagodzinski Serena Spudich Nelson Michael Jerome H Kim Victor Valcour RV254/SEARCH 010 protocol teams |
| author_sort | Napapon Sailasuta |
| collection | DOAJ |
| description | <h4>Objective</h4>Single voxel proton magnetic resonance spectroscopy (MRS) can be used to monitor changes in brain inflammation and neuronal integrity associated with HIV infection and its treatments. We used MRS to measure brain changes during the first weeks following HIV infection and in response to antiretroviral therapy (ART).<h4>Methods</h4>Brain metabolite levels of N-acetyl aspartate (NAA), choline (tCHO), creatine (CR), myoinositol (MI), and glutamate and glutamine (GLX) were measured in acute HIV subjects (n = 31) and compared to chronic HIV+individuals (n = 26) and HIV negative control subjects (n = 10) from Bangkok, Thailand. Metabolites were measured in frontal gray matter (FGM), frontal white matter (FWM), occipital gray matter (OGM), and basal ganglia (BG). Repeat measures were obtained in 17 acute subjects 1, 3 and 6 months following initiation of ART.<h4>Results</h4>After adjustment for age we identified elevated BG tCHO/CR in acute HIV cases at baseline (median 14 days after HIV infection) compared to control (p = 0.0014), as well as chronic subjects (p = 0.0023). A similar tCHO/CR elevation was noted in OGM; no other metabolite abnormalities were seen between acute and control subjects. Mixed longitudinal models revealed resolution of BG tCHO/CR elevation after ART (p = 0.022) with tCHO/CR similar to control subjects at 6 months.<h4>Interpretation</h4>We detected cellular inflammation in the absence of measurable neuronal injury within the first month of HIV infection, and normalization of this inflammation following acutely administered ART. Our findings suggest that early ART may be neuroprotective in HIV infection by mitigating processes leading to CNS injury. |
| format | Article |
| id | doaj-art-cfb7c5fb3e26477f81b584fcec43b2bb |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-cfb7c5fb3e26477f81b584fcec43b2bb2025-08-20T03:09:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4927210.1371/journal.pone.0049272Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection.Napapon SailasutaWilliam RossJintanat AnanworanichThep ChalermchaiVictor DeGruttolaSukalaya LerdlumMantana PothisriEdgar BusovacaSilvia Ratto-KimLinda JagodzinskiSerena SpudichNelson MichaelJerome H KimVictor ValcourRV254/SEARCH 010 protocol teams<h4>Objective</h4>Single voxel proton magnetic resonance spectroscopy (MRS) can be used to monitor changes in brain inflammation and neuronal integrity associated with HIV infection and its treatments. We used MRS to measure brain changes during the first weeks following HIV infection and in response to antiretroviral therapy (ART).<h4>Methods</h4>Brain metabolite levels of N-acetyl aspartate (NAA), choline (tCHO), creatine (CR), myoinositol (MI), and glutamate and glutamine (GLX) were measured in acute HIV subjects (n = 31) and compared to chronic HIV+individuals (n = 26) and HIV negative control subjects (n = 10) from Bangkok, Thailand. Metabolites were measured in frontal gray matter (FGM), frontal white matter (FWM), occipital gray matter (OGM), and basal ganglia (BG). Repeat measures were obtained in 17 acute subjects 1, 3 and 6 months following initiation of ART.<h4>Results</h4>After adjustment for age we identified elevated BG tCHO/CR in acute HIV cases at baseline (median 14 days after HIV infection) compared to control (p = 0.0014), as well as chronic subjects (p = 0.0023). A similar tCHO/CR elevation was noted in OGM; no other metabolite abnormalities were seen between acute and control subjects. Mixed longitudinal models revealed resolution of BG tCHO/CR elevation after ART (p = 0.022) with tCHO/CR similar to control subjects at 6 months.<h4>Interpretation</h4>We detected cellular inflammation in the absence of measurable neuronal injury within the first month of HIV infection, and normalization of this inflammation following acutely administered ART. Our findings suggest that early ART may be neuroprotective in HIV infection by mitigating processes leading to CNS injury.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049272&type=printable |
| spellingShingle | Napapon Sailasuta William Ross Jintanat Ananworanich Thep Chalermchai Victor DeGruttola Sukalaya Lerdlum Mantana Pothisri Edgar Busovaca Silvia Ratto-Kim Linda Jagodzinski Serena Spudich Nelson Michael Jerome H Kim Victor Valcour RV254/SEARCH 010 protocol teams Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. PLoS ONE |
| title | Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. |
| title_full | Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. |
| title_fullStr | Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. |
| title_full_unstemmed | Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. |
| title_short | Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. |
| title_sort | change in brain magnetic resonance spectroscopy after treatment during acute hiv infection |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049272&type=printable |
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