Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

Concerning the dismal prognosis of chemoresistant patients with epithelial ovarian carcinoma (EOC), we aimed to follow up the findings of a previous whole-exome sequencing study using an orthogonal Sanger sequencing on the same patients and a separate set of 127 EOC patients (N = 177, all fresh froz...

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Main Authors: Al Obeed Allah Mohammad, Ali Esraa, Krus Ivona, Holý Petr, Haničinec Vojtěch, Ambrozkiewicz Filip, Rob Lukáš, Hruda Martin, Mrhalová Marcela, Kopečková Kateřina, Bartáková Alena, Bouda Jiří, Spálenková Alžběta, Souček Pavel, Václavíková Radka
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Cancer Biology & Therapy
Subjects:
Epithelial ovarian carcinoma
platinum sensitivity
TP53
KRAS
variant
transcript expression
Online Access:https://www.tandfonline.com/doi/10.1080/15384047.2025.2543105
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