Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from NHANES
Abstract The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel lipid index. Prior research has established a connection between lipid irregularities and chronic kidney disease (CKD). This study aims to establish a possible link between NHHR and...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-96299-7 |
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| author | Yifan Sun Zhou Li Ninghan Feng |
| author_facet | Yifan Sun Zhou Li Ninghan Feng |
| author_sort | Yifan Sun |
| collection | DOAJ |
| description | Abstract The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel lipid index. Prior research has established a connection between lipid irregularities and chronic kidney disease (CKD). This study aims to establish a possible link between NHHR and CKD. Data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2003 to 2016 was used to examine the relationship between NHHR and CKD among the elderly population. This research utilized weighted logistic regression, smoothed curve fitting and subgroup analyses along with interaction tests to evaluate the association between NHHR and CKD. The findings reveal a positive correlation between NHHR and CKD in fully adjusted Model 3. Besides, NHHR had a J-curve relationship with CKD. Subgroup analysis indicated that compared with those with lower body mass index (BMI), individuals with higher BMI are more prone to CKD. Research has shown that increased NHHR levels are associated with a higher likelihood of developing CKD in individuals aged above 60 in the United States. NHHR’s role in lipid metabolism suggests it might be an effective marker for tracking CKD’s progression. |
| format | Article |
| id | doaj-art-cfb1a337a7a6430dab4fd2c131ed102f |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-cfb1a337a7a6430dab4fd2c131ed102f2025-08-20T02:11:42ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-96299-7Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from NHANESYifan Sun0Zhou Li1Ninghan Feng2Department of Urology, Jiangnan University Medical CenterDepartment of Urology, Nanjing Medical UniversityDepartment of Urology, Jiangnan University Medical CenterAbstract The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel lipid index. Prior research has established a connection between lipid irregularities and chronic kidney disease (CKD). This study aims to establish a possible link between NHHR and CKD. Data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2003 to 2016 was used to examine the relationship between NHHR and CKD among the elderly population. This research utilized weighted logistic regression, smoothed curve fitting and subgroup analyses along with interaction tests to evaluate the association between NHHR and CKD. The findings reveal a positive correlation between NHHR and CKD in fully adjusted Model 3. Besides, NHHR had a J-curve relationship with CKD. Subgroup analysis indicated that compared with those with lower body mass index (BMI), individuals with higher BMI are more prone to CKD. Research has shown that increased NHHR levels are associated with a higher likelihood of developing CKD in individuals aged above 60 in the United States. NHHR’s role in lipid metabolism suggests it might be an effective marker for tracking CKD’s progression.https://doi.org/10.1038/s41598-025-96299-7NHHRNHANESCKDCross-sectional studyObesityElderly |
| spellingShingle | Yifan Sun Zhou Li Ninghan Feng Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from NHANES Scientific Reports NHHR NHANES CKD Cross-sectional study Obesity Elderly |
| title | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from NHANES |
| title_full | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from NHANES |
| title_fullStr | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from NHANES |
| title_full_unstemmed | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from NHANES |
| title_short | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from NHANES |
| title_sort | association of non high density lipoprotein cholesterol to high density lipoprotein cholesterol ratio and chronic kidney disease in elderly insights from nhanes |
| topic | NHHR NHANES CKD Cross-sectional study Obesity Elderly |
| url | https://doi.org/10.1038/s41598-025-96299-7 |
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