Leveraging Microorganisms to Combat Skin Cancer
Skin cancer, including melanoma and non-melanoma types, presents a significant and growing global health challenge due to its increasing incidence and mortality rates. While conventional treatments such as surgical excision, immunotherapy, and targeted therapies are well-established, microorganism-b...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/13/2/462 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850231557228331008 |
|---|---|
| author | Hayden J. Oyler Austen W. Callister Makenzi N. Kutch Mark R. Wakefield Yujiang Fang |
| author_facet | Hayden J. Oyler Austen W. Callister Makenzi N. Kutch Mark R. Wakefield Yujiang Fang |
| author_sort | Hayden J. Oyler |
| collection | DOAJ |
| description | Skin cancer, including melanoma and non-melanoma types, presents a significant and growing global health challenge due to its increasing incidence and mortality rates. While conventional treatments such as surgical excision, immunotherapy, and targeted therapies are well-established, microorganism-based approaches represent an innovative and promising alternative. These therapies employ live, genetically engineered, or commensal bacteria, viral vectors, or bacterial components to achieve various therapeutic mechanisms, including tumor targeting, immune system modulation, vascular disruption, competitive exclusion, drug delivery, and direct oncolysis. Despite their potential, these approaches require further investigation to address safety concerns, optimize treatment protocols, and gain a comprehensive understanding of their long-term outcomes. |
| format | Article |
| id | doaj-art-cfb14b3c210d435ca667523fc84cbcf3 |
| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-cfb14b3c210d435ca667523fc84cbcf32025-08-20T02:03:28ZengMDPI AGMicroorganisms2076-26072025-02-0113246210.3390/microorganisms13020462Leveraging Microorganisms to Combat Skin CancerHayden J. Oyler0Austen W. Callister1Makenzi N. Kutch2Mark R. Wakefield3Yujiang Fang4Department of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USASpencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT 84132, USADepartment of Surgery, School of Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Surgery, School of Medicine, University of Missouri, Columbia, MO 65211, USADepartment of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USASkin cancer, including melanoma and non-melanoma types, presents a significant and growing global health challenge due to its increasing incidence and mortality rates. While conventional treatments such as surgical excision, immunotherapy, and targeted therapies are well-established, microorganism-based approaches represent an innovative and promising alternative. These therapies employ live, genetically engineered, or commensal bacteria, viral vectors, or bacterial components to achieve various therapeutic mechanisms, including tumor targeting, immune system modulation, vascular disruption, competitive exclusion, drug delivery, and direct oncolysis. Despite their potential, these approaches require further investigation to address safety concerns, optimize treatment protocols, and gain a comprehensive understanding of their long-term outcomes.https://www.mdpi.com/2076-2607/13/2/462skin cancer treatmentmicroorganism cancer treatmentskin microbiotaprobioticsnanocarriersoncolytic viruses |
| spellingShingle | Hayden J. Oyler Austen W. Callister Makenzi N. Kutch Mark R. Wakefield Yujiang Fang Leveraging Microorganisms to Combat Skin Cancer Microorganisms skin cancer treatment microorganism cancer treatment skin microbiota probiotics nanocarriers oncolytic viruses |
| title | Leveraging Microorganisms to Combat Skin Cancer |
| title_full | Leveraging Microorganisms to Combat Skin Cancer |
| title_fullStr | Leveraging Microorganisms to Combat Skin Cancer |
| title_full_unstemmed | Leveraging Microorganisms to Combat Skin Cancer |
| title_short | Leveraging Microorganisms to Combat Skin Cancer |
| title_sort | leveraging microorganisms to combat skin cancer |
| topic | skin cancer treatment microorganism cancer treatment skin microbiota probiotics nanocarriers oncolytic viruses |
| url | https://www.mdpi.com/2076-2607/13/2/462 |
| work_keys_str_mv | AT haydenjoyler leveragingmicroorganismstocombatskincancer AT austenwcallister leveragingmicroorganismstocombatskincancer AT makenzinkutch leveragingmicroorganismstocombatskincancer AT markrwakefield leveragingmicroorganismstocombatskincancer AT yujiangfang leveragingmicroorganismstocombatskincancer |