The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI
BackgroundChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition in urology characterized by chronic pain. The pathogenesis of CP/CPPS remains unclear.MethodsWe enrolled 45 eligible CP/CPPS patients and 45 healthy volunteers. We evaluated their resting-state fMRI data us...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1511654/full |
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| author | Shengyang Ge Yunting Xiang Xuyun Hua Zening Wang Qingfeng Hu Yijun Guo Jingqiang Huang Chengpeng Zhao Jiajia Wu Xianli Wang Chuanyu Sun |
| author_facet | Shengyang Ge Yunting Xiang Xuyun Hua Zening Wang Qingfeng Hu Yijun Guo Jingqiang Huang Chengpeng Zhao Jiajia Wu Xianli Wang Chuanyu Sun |
| author_sort | Shengyang Ge |
| collection | DOAJ |
| description | BackgroundChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition in urology characterized by chronic pain. The pathogenesis of CP/CPPS remains unclear.MethodsWe enrolled 45 eligible CP/CPPS patients and 45 healthy volunteers. We evaluated their resting-state fMRI data using a comprehensive set of parameters, such as Regional Homogeneity (ReHo) and Degree Centrality (DC), to detect brain abnormalities and identify potential correlates with the clinical manifestations of CP/CPPS. We further categorized the patients into subgroups according to their scores of NIH-CPSI to elucidate the brain changes associated with differing symptom severities.ResultsProfound alterations in brain function were observed in patients with CP/CPPS. These changes involved multiple brain regions identified by DC analysis, including the right anterior cingulate cortex (ACC), left inferior frontal opercular cortex, left amygdala, right middle frontal cortex, and bilateral insula. ReHo analysis revealed significant changes in the right thalamus, left inferior frontal triangular cortex, right superior temporal pole, left ACC, and right superior frontal cortex (cluster >20 voxels, GRF correction, p < 0.05). Analysis using ReHo and DC revealed that brain alterations associated with varying symptom severities were localized in pain perception and modulation regions. Specifically, the DC values in the right ACC showed a linear correlation with the severity of symptoms measured by the NIH-CPSI (AUC = 0.9654, p < 0.0001).ConclusionIn CP/CPPS, we first discovered differences in brain function among patients with varying degrees of severity. The brain alterations of DC in the right ACC might be a potential biomarker for diagnosing and assessing disease severity. |
| format | Article |
| id | doaj-art-cfb0bbeba073418d88392b6e00b3e8e1 |
| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-cfb0bbeba073418d88392b6e00b3e8e12025-08-20T03:12:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-02-011910.3389/fnins.2025.15116541511654The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSIShengyang Ge0Yunting Xiang1Xuyun Hua2Zening Wang3Qingfeng Hu4Yijun Guo5Jingqiang Huang6Chengpeng Zhao7Jiajia Wu8Xianli Wang9Chuanyu Sun10Institute of Biomedical Sciences, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Biomedical Sciences, Fudan University, Shanghai, ChinaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Urology, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, ChinaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, ChinaBackgroundChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition in urology characterized by chronic pain. The pathogenesis of CP/CPPS remains unclear.MethodsWe enrolled 45 eligible CP/CPPS patients and 45 healthy volunteers. We evaluated their resting-state fMRI data using a comprehensive set of parameters, such as Regional Homogeneity (ReHo) and Degree Centrality (DC), to detect brain abnormalities and identify potential correlates with the clinical manifestations of CP/CPPS. We further categorized the patients into subgroups according to their scores of NIH-CPSI to elucidate the brain changes associated with differing symptom severities.ResultsProfound alterations in brain function were observed in patients with CP/CPPS. These changes involved multiple brain regions identified by DC analysis, including the right anterior cingulate cortex (ACC), left inferior frontal opercular cortex, left amygdala, right middle frontal cortex, and bilateral insula. ReHo analysis revealed significant changes in the right thalamus, left inferior frontal triangular cortex, right superior temporal pole, left ACC, and right superior frontal cortex (cluster >20 voxels, GRF correction, p < 0.05). Analysis using ReHo and DC revealed that brain alterations associated with varying symptom severities were localized in pain perception and modulation regions. Specifically, the DC values in the right ACC showed a linear correlation with the severity of symptoms measured by the NIH-CPSI (AUC = 0.9654, p < 0.0001).ConclusionIn CP/CPPS, we first discovered differences in brain function among patients with varying degrees of severity. The brain alterations of DC in the right ACC might be a potential biomarker for diagnosing and assessing disease severity.https://www.frontiersin.org/articles/10.3389/fnins.2025.1511654/fullCP/CPPSfMRINIH-CPSIhierarchical clusteringchronic pain |
| spellingShingle | Shengyang Ge Yunting Xiang Xuyun Hua Zening Wang Qingfeng Hu Yijun Guo Jingqiang Huang Chengpeng Zhao Jiajia Wu Xianli Wang Chuanyu Sun The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI Frontiers in Neuroscience CP/CPPS fMRI NIH-CPSI hierarchical clustering chronic pain |
| title | The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI |
| title_full | The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI |
| title_fullStr | The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI |
| title_full_unstemmed | The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI |
| title_short | The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI |
| title_sort | characteristics of brain function alterations in patients with chronic prostatitis chronic pelvic pain syndrome across varying symptom severities evaluated by nih cpsi |
| topic | CP/CPPS fMRI NIH-CPSI hierarchical clustering chronic pain |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1511654/full |
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