Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Abstract Despite its promise, cardiac regenerative therapy remains clinically elusive due to the difficulty of spatio‐temporal control of proliferative induction, and the need to coordinately reprogram multiple regulatory pathways to overcome the strict post‐mitotic state of human adult cardiomyocyt...

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Bibliographic Details
Main Authors: Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
cardiac organoids
cardiomyocyte proliferation
microRNAs
myocardial infarction
Online Access:https://doi.org/10.1002/advs.202414455
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