Digesting the crisis: autophagy and coronaviruses
Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the in...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2020-05-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/2020a-carmona-gutierrez-microbial-cell/ |
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| author | Didac Carmona-Gutierrez Maria A. Bauer Andreas Zimmermann Katharina Kainz Sebastian J. Hofer Guido Kroemer Frank Madeo |
| author_facet | Didac Carmona-Gutierrez Maria A. Bauer Andreas Zimmermann Katharina Kainz Sebastian J. Hofer Guido Kroemer Frank Madeo |
| author_sort | Didac Carmona-Gutierrez |
| collection | DOAJ |
| description | Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions. |
| format | Article |
| id | doaj-art-cfaac2a770bf47858ae4043b9ccb3c13 |
| institution | OA Journals |
| issn | 2311-2638 |
| language | English |
| publishDate | 2020-05-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-cfaac2a770bf47858ae4043b9ccb3c132025-08-20T02:04:34ZengShared Science Publishers OGMicrobial Cell2311-26382020-05-017511912810.15698/mic2020.05.715Digesting the crisis: autophagy and coronavirusesDidac Carmona-Gutierrez0Maria A. Bauer1Andreas Zimmermann2Katharina Kainz3Sebastian J. Hofer4Guido Kroemer5Frank Madeo6Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, INSERM U1138, Institut Universitaire de France, Paris, France.Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.http://microbialcell.com/researcharticles/2020a-carmona-gutierrez-microbial-cell/covid-19sarssars-cov-2merscoronavirusvirophagyinflammationimmunity |
| spellingShingle | Didac Carmona-Gutierrez Maria A. Bauer Andreas Zimmermann Katharina Kainz Sebastian J. Hofer Guido Kroemer Frank Madeo Digesting the crisis: autophagy and coronaviruses Microbial Cell covid-19 sars sars-cov-2 mers coronavirus virophagy inflammation immunity |
| title | Digesting the crisis: autophagy and coronaviruses |
| title_full | Digesting the crisis: autophagy and coronaviruses |
| title_fullStr | Digesting the crisis: autophagy and coronaviruses |
| title_full_unstemmed | Digesting the crisis: autophagy and coronaviruses |
| title_short | Digesting the crisis: autophagy and coronaviruses |
| title_sort | digesting the crisis autophagy and coronaviruses |
| topic | covid-19 sars sars-cov-2 mers coronavirus virophagy inflammation immunity |
| url | http://microbialcell.com/researcharticles/2020a-carmona-gutierrez-microbial-cell/ |
| work_keys_str_mv | AT didaccarmonagutierrez digestingthecrisisautophagyandcoronaviruses AT mariaabauer digestingthecrisisautophagyandcoronaviruses AT andreaszimmermann digestingthecrisisautophagyandcoronaviruses AT katharinakainz digestingthecrisisautophagyandcoronaviruses AT sebastianjhofer digestingthecrisisautophagyandcoronaviruses AT guidokroemer digestingthecrisisautophagyandcoronaviruses AT frankmadeo digestingthecrisisautophagyandcoronaviruses |