Aging-related alternative splicing drive neoantigen emergence revealed by transcriptome analysis of 1,255 human blood samples

Aging-related alternative splicing drive neoantigen emergence revealed by transcriptome analysis of 1,255 human blood samples

This study aimed to identify age-related genes and alternative splicing (AS) events by comprehensive transcriptome analysis of 1,255 healthy blood samples from individuals aged 8–87 years. We identified 1,029 up-regulated and 1,186 down-regulated genes in older individuals, including 17 genes overla...

Full description

Saved in:
Bibliographic Details
Main Authors: Shuhan Li, Haohao Lv, Renxin Zhang, Jinjun Li, Zhiyuan Chen, Naixue Yang, Shaoxing Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Aging
Subjects:
aging
transcriptome analysis
alternative splicing
immunosenescence
neoantigens
anti-aging immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2025.1575862/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items