Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature
Progressive nodular histiocytosis (PNH) is a rare condition characterized by progressive eruption of multiple yellowish-brown papules and nodules on the skin and mucous membranes. We present the case of a 37-year-old Caucasian man with gradually increased appearance of nodular lesions on the forehea...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/5531820 |
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| author | Numbereye Numbere Tatsiana Pukhalskaya Blythe Bowman Katelynn Campbell Bruce Smoller |
| author_facet | Numbereye Numbere Tatsiana Pukhalskaya Blythe Bowman Katelynn Campbell Bruce Smoller |
| author_sort | Numbereye Numbere |
| collection | DOAJ |
| description | Progressive nodular histiocytosis (PNH) is a rare condition characterized by progressive eruption of multiple yellowish-brown papules and nodules on the skin and mucous membranes. We present the case of a 37-year-old Caucasian man with gradually increased appearance of nodular lesions on the forehead and right temple. These lesions were initially diagnosed as xanthomas and did not respond to intralesional injections of triamcinolone. Additional biopsy revealed an intense dermal infiltrate of foamy mononuclear epithelioid cells with a minor admixture of plasma cells, lymphocytes, and scattered multinucleated giant cells. On immunohistochemical staining, the lesional cells were positive for CD163 and CD68 and negative for CD1a, thus confirming a mononuclear-macrophage lineage. The clinical presentation and the histological impression lead to the diagnosis of PNH. This condition could be challenging, mimicking microscopically similar lesions of the non-Langerhans cell histiocytosis group. Although uncommon, PNH stands out due to its clinical and microscopic features and should be taken into consideration in the differential diagnosis of cutaneous histiocytoses. |
| format | Article |
| id | doaj-art-cfa4e0a4d63c4273aeac87853cdff553 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-cfa4e0a4d63c4273aeac87853cdff5532025-02-03T01:27:06ZengWileyCase Reports in Pathology2090-67812090-679X2021-01-01202110.1155/2021/55318205531820Progressive Nodular Histiocytosis: Report of a Case and Review of the LiteratureNumbereye Numbere0Tatsiana Pukhalskaya1Blythe Bowman2Katelynn Campbell3Bruce Smoller4Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USADepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USADermatology Group of Arkansas, Little Rock, Arkansas, USADepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USADepartment of Pathology and Laboratory Medicine and Department of Dermatology, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, New York, USAProgressive nodular histiocytosis (PNH) is a rare condition characterized by progressive eruption of multiple yellowish-brown papules and nodules on the skin and mucous membranes. We present the case of a 37-year-old Caucasian man with gradually increased appearance of nodular lesions on the forehead and right temple. These lesions were initially diagnosed as xanthomas and did not respond to intralesional injections of triamcinolone. Additional biopsy revealed an intense dermal infiltrate of foamy mononuclear epithelioid cells with a minor admixture of plasma cells, lymphocytes, and scattered multinucleated giant cells. On immunohistochemical staining, the lesional cells were positive for CD163 and CD68 and negative for CD1a, thus confirming a mononuclear-macrophage lineage. The clinical presentation and the histological impression lead to the diagnosis of PNH. This condition could be challenging, mimicking microscopically similar lesions of the non-Langerhans cell histiocytosis group. Although uncommon, PNH stands out due to its clinical and microscopic features and should be taken into consideration in the differential diagnosis of cutaneous histiocytoses.http://dx.doi.org/10.1155/2021/5531820 |
| spellingShingle | Numbereye Numbere Tatsiana Pukhalskaya Blythe Bowman Katelynn Campbell Bruce Smoller Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature Case Reports in Pathology |
| title | Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature |
| title_full | Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature |
| title_fullStr | Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature |
| title_full_unstemmed | Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature |
| title_short | Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature |
| title_sort | progressive nodular histiocytosis report of a case and review of the literature |
| url | http://dx.doi.org/10.1155/2021/5531820 |
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