Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis
ABSTRACT: Introduction: Orthobiologics, such as mesenchymal stem cells (MSCs), known for their multipotency, are key players in stem cell therapy. One of the ways MSCs realize their therapeutic potential is through the release of extracellular vesicles (EVs), small lipid-membrane–bound structures t...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Cartilage & Joint Preservation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667254524000568 |
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| author | Pooja N. Swami Henintsoa Fanjaniaina Andriamifidy Shabirul Haque Timothy Reed Azhar Khan Daniel A. Grande |
| author_facet | Pooja N. Swami Henintsoa Fanjaniaina Andriamifidy Shabirul Haque Timothy Reed Azhar Khan Daniel A. Grande |
| author_sort | Pooja N. Swami |
| collection | DOAJ |
| description | ABSTRACT: Introduction: Orthobiologics, such as mesenchymal stem cells (MSCs), known for their multipotency, are key players in stem cell therapy. One of the ways MSCs realize their therapeutic potential is through the release of extracellular vesicles (EVs), small lipid-membrane–bound structures that carry bioactive materials from their progenitor cells. Objectives: This review aims to provide an overview of EVs in and from the synovial joint in both physiological and pathological context specifically in osteoarthritis. Methods: This narrative review synthesizes findings from PubMed using keywords—orthobiologics, EVs, synovial joint EVs, osteoarthritis, and synovial fluid. This review focuses on the potential of EVs isolated from different sources of MSCs found in the synovial joint, evaluating their differentiation capacity and contributions to joint health and osteoarthritis. Results: EVs from various MSC types show promising results for osteochondral regeneration. However, the differentiation potential and therapeutic efficacy vary among cell types. Understanding the dynamic nature of the biological function of these cell types that serve as sources of EVs is essential for predicting their therapeutic actions. The synovium itself is identified as a significant source of EVs, which may offer unique applications for treating osteoarthritis and cartilage defects. Conclusions: EVs and exosomes play a critical role in cartilage and osteochondral defect repair. They exhibit preservative and restorative benefits for tissue injuries, highlighting their potential in treating osteoarthritis and cartilage defects. Additionally, the synovium, as a source of EVs and exosomes, presents unique therapeutic applications as orthobiologic. |
| format | Article |
| id | doaj-art-cf91d506640f4fdbbb1cdccd36db3e45 |
| institution | Kabale University |
| issn | 2667-2545 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cartilage & Joint Preservation |
| spelling | doaj-art-cf91d506640f4fdbbb1cdccd36db3e452024-12-10T04:14:50ZengElsevierJournal of Cartilage & Joint Preservation2667-25452024-12-0144100220Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritisPooja N. Swami0Henintsoa Fanjaniaina Andriamifidy1Shabirul Haque2Timothy Reed3Azhar Khan4Daniel A. Grande5Orthopaedic Research Department, Feinstein Institute for Medical Research, Northwell Health, New York, NY, USA; Department of Biotechnology, Shoolini University, Bajhol, Solan, Himachal Pradesh, India; Pooja N. Swami, Orthopaedic Research Department, Feinstein Institute for Medical Research, Northwell Health, 350 Community Drive, Manhasset, New York, NY 11030.Orthopaedic Research Department, Feinstein Institute for Medical Research, Northwell Health, New York, NY, USADepartment of Autoimmune Diseases, Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY, USADepartment of Orthopaedic Surgery, Huntington Hospital, Northwell Health, Huntington, NY, USADepartment of Biotechnology, Shoolini University, Bajhol, Solan, Himachal Pradesh, IndiaOrthopaedic Research Department, Feinstein Institute for Medical Research, Northwell Health, New York, NY, USA; Daniel A. Grande, Orthopaedic Research Department, Feinstein Institute for Medical Research, Northwell Health, 350 Community Drive, Manhasset, New York, NY 11030.ABSTRACT: Introduction: Orthobiologics, such as mesenchymal stem cells (MSCs), known for their multipotency, are key players in stem cell therapy. One of the ways MSCs realize their therapeutic potential is through the release of extracellular vesicles (EVs), small lipid-membrane–bound structures that carry bioactive materials from their progenitor cells. Objectives: This review aims to provide an overview of EVs in and from the synovial joint in both physiological and pathological context specifically in osteoarthritis. Methods: This narrative review synthesizes findings from PubMed using keywords—orthobiologics, EVs, synovial joint EVs, osteoarthritis, and synovial fluid. This review focuses on the potential of EVs isolated from different sources of MSCs found in the synovial joint, evaluating their differentiation capacity and contributions to joint health and osteoarthritis. Results: EVs from various MSC types show promising results for osteochondral regeneration. However, the differentiation potential and therapeutic efficacy vary among cell types. Understanding the dynamic nature of the biological function of these cell types that serve as sources of EVs is essential for predicting their therapeutic actions. The synovium itself is identified as a significant source of EVs, which may offer unique applications for treating osteoarthritis and cartilage defects. Conclusions: EVs and exosomes play a critical role in cartilage and osteochondral defect repair. They exhibit preservative and restorative benefits for tissue injuries, highlighting their potential in treating osteoarthritis and cartilage defects. Additionally, the synovium, as a source of EVs and exosomes, presents unique therapeutic applications as orthobiologic.http://www.sciencedirect.com/science/article/pii/S2667254524000568ExosomesOsteoarthritisSynovial fibroblastsSynovial fluidSynovial MSCs |
| spellingShingle | Pooja N. Swami Henintsoa Fanjaniaina Andriamifidy Shabirul Haque Timothy Reed Azhar Khan Daniel A. Grande Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis Journal of Cartilage & Joint Preservation Exosomes Osteoarthritis Synovial fibroblasts Synovial fluid Synovial MSCs |
| title | Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis |
| title_full | Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis |
| title_fullStr | Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis |
| title_full_unstemmed | Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis |
| title_short | Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis |
| title_sort | exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis |
| topic | Exosomes Osteoarthritis Synovial fibroblasts Synovial fluid Synovial MSCs |
| url | http://www.sciencedirect.com/science/article/pii/S2667254524000568 |
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