HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis

HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis

Acute kidney injury (AKI) refers to clinical syndromes culminating in rapidly reduced renal function associated with inflammation and the demise of renal tubular epithelial cells. Current research aims to develop strategies which prevent tubular cell death. Here, based on the involvement of histone...

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Bibliographic Details
Main Authors: Manman Xie, Rui Hou, Runrun Shan, Xinyu Cheng, Pengcheng Wu, Xiufeng Luo, Yangyang Wei, Li Gao, Xiaoying Liu, Qi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
acute kidney injury
necroptosis
RGFP966
inflammation
HDAC3 abbreviations Cr: creatinine
RG: RGFP966
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1546950/full
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