Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles
Antibiotic therapy relies on understanding both pharmacokinetics (PK) and pharmacodynamics (PD), which respectively address drug absorption, distribution, and elimination, and the relationship between drug concentration and antimicrobial efficacy. This review synthesizes decades of research, drawing...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1521091/full |
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| author | Mohammad Sina Alikhani Mohsen Nazari Mohsen Nazari Shima Hatamkhani |
| author_facet | Mohammad Sina Alikhani Mohsen Nazari Mohsen Nazari Shima Hatamkhani |
| author_sort | Mohammad Sina Alikhani |
| collection | DOAJ |
| description | Antibiotic therapy relies on understanding both pharmacokinetics (PK) and pharmacodynamics (PD), which respectively address drug absorption, distribution, and elimination, and the relationship between drug concentration and antimicrobial efficacy. This review synthesizes decades of research, drawing from in-vitro studies, in-vivo models, and clinical observations, to elucidate the temporal dynamics of antibiotic activity. We explore how these dynamics, including concentration-effect relationships and post antibiotic effects, inform the classification of antibiotics based on their PD profiles. Additionally, we discuss the pivotal role of PK/PD principles in determining optimal dosage regimens. By providing a comprehensive overview of PK/PD principles in antibiotic therapy, this review aims to enhance understanding and improve treatment outcomes in clinical practice. |
| format | Article |
| id | doaj-art-cf8b467fc5a44f54af88ef2c389f514f |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-cf8b467fc5a44f54af88ef2c389f514f2025-08-20T03:11:17ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-02-011510.3389/fcimb.2025.15210911521091Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principlesMohammad Sina Alikhani0Mohsen Nazari1Mohsen Nazari2Shima Hatamkhani3Student Research Committee, Urmia University of Medical Sciences, Urmia, IranDepartment of Microbiology, Hamadan University of Medical Sciences, Hamadan, IranInfectious Disease Research Center, Avicenna Institute of Clinical Sciences, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Clinical Pharmacy, School of Pharmacy, Urmia University of Medical Sciences, Urmia, IranAntibiotic therapy relies on understanding both pharmacokinetics (PK) and pharmacodynamics (PD), which respectively address drug absorption, distribution, and elimination, and the relationship between drug concentration and antimicrobial efficacy. This review synthesizes decades of research, drawing from in-vitro studies, in-vivo models, and clinical observations, to elucidate the temporal dynamics of antibiotic activity. We explore how these dynamics, including concentration-effect relationships and post antibiotic effects, inform the classification of antibiotics based on their PD profiles. Additionally, we discuss the pivotal role of PK/PD principles in determining optimal dosage regimens. By providing a comprehensive overview of PK/PD principles in antibiotic therapy, this review aims to enhance understanding and improve treatment outcomes in clinical practice.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1521091/fullpharmacokineticpharmacodynamicantibioticsantimicrobial efficacypost-antibiotic effect |
| spellingShingle | Mohammad Sina Alikhani Mohsen Nazari Mohsen Nazari Shima Hatamkhani Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles Frontiers in Cellular and Infection Microbiology pharmacokinetic pharmacodynamic antibiotics antimicrobial efficacy post-antibiotic effect |
| title | Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles |
| title_full | Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles |
| title_fullStr | Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles |
| title_full_unstemmed | Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles |
| title_short | Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles |
| title_sort | enhancing antibiotic therapy through comprehensive pharmacokinetic pharmacodynamic principles |
| topic | pharmacokinetic pharmacodynamic antibiotics antimicrobial efficacy post-antibiotic effect |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1521091/full |
| work_keys_str_mv | AT mohammadsinaalikhani enhancingantibiotictherapythroughcomprehensivepharmacokineticpharmacodynamicprinciples AT mohsennazari enhancingantibiotictherapythroughcomprehensivepharmacokineticpharmacodynamicprinciples AT mohsennazari enhancingantibiotictherapythroughcomprehensivepharmacokineticpharmacodynamicprinciples AT shimahatamkhani enhancingantibiotictherapythroughcomprehensivepharmacokineticpharmacodynamicprinciples |