Impact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndrome
Abstract Background Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) are both common endocrine disorders. This study investigates the impact of SCH on the endocrine features of patients diagnosed with PCOS. Methods This retrospective study included 124 women diagnosed with PCOS...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-025-02910-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849237639623868416 |
|---|---|
| author | Rui Hua Jing-Jun Li Wei Yang Yun Hua Yu-Long Ma |
| author_facet | Rui Hua Jing-Jun Li Wei Yang Yun Hua Yu-Long Ma |
| author_sort | Rui Hua |
| collection | DOAJ |
| description | Abstract Background Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) are both common endocrine disorders. This study investigates the impact of SCH on the endocrine features of patients diagnosed with PCOS. Methods This retrospective study included 124 women diagnosed with PCOS between January 2020 and November 2022. Participants were divided into two groups: those with PCOS alone (n = 93) and those with both PCOS and SCH (n = 31).Clinical parameters (age, body mass index, blood pressure, age at menarche) and endocrine markers were collected. Hormonal measurements included follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), testosterone (TES), progesterone (PRG), TSH, free triiodothyronine (FT3), FT4, and Anti-Müllerian hormone (AMH). Thyroid autoantibodies, including antithyroid peroxidase (TPO-Ab) and antithyroglobulin antibody (TG-Ab), were also assessed. Antral follicle count (AFC) was evaluated using transvaginal ultrasound. Results The study found that patients with PCOS and SCH exhibited significantly higher levels of TSH and PRL compared to those with PCOS alone. However, there were no significant differences in PRG, LH, FSH, TES, and E2 levels between the groups. The PCOS group showed a moderate positive correlation between TSH and AMH, whereas the PCOS with SCH group demonstrated a negative correlation between TSH and FSH, albeit not statistically significant. Conclusions Subclinical hypothyroidism in women with PCOS is associated with altered thyroid–prolactin axis activity and a disrupted correlation between TSH and AMH, while gonadotropin levels and ovarian morphology appear unaffected. These findings warrant confirmation through prospective studies. |
| format | Article |
| id | doaj-art-cf853fc1d3dd4123ab0b85124662b7f0 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-cf853fc1d3dd4123ab0b85124662b7f02025-08-20T04:01:53ZengBMCEuropean Journal of Medical Research2047-783X2025-08-013011710.1186/s40001-025-02910-yImpact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndromeRui Hua0Jing-Jun Li1Wei Yang2Yun Hua3Yu-Long Ma4Department of General Practice, Xinxiang Central HospitalDepartment of General Practice, Xinxiang Central HospitalDepartment of Cardiovascular Medicine, Luohe Central HospitalBiology Department, Xinxiang No. 1 Middle SchoolDepartment of General Practice, Xinxiang Central HospitalAbstract Background Polycystic ovary syndrome (PCOS) and subclinical hypothyroidism (SCH) are both common endocrine disorders. This study investigates the impact of SCH on the endocrine features of patients diagnosed with PCOS. Methods This retrospective study included 124 women diagnosed with PCOS between January 2020 and November 2022. Participants were divided into two groups: those with PCOS alone (n = 93) and those with both PCOS and SCH (n = 31).Clinical parameters (age, body mass index, blood pressure, age at menarche) and endocrine markers were collected. Hormonal measurements included follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), testosterone (TES), progesterone (PRG), TSH, free triiodothyronine (FT3), FT4, and Anti-Müllerian hormone (AMH). Thyroid autoantibodies, including antithyroid peroxidase (TPO-Ab) and antithyroglobulin antibody (TG-Ab), were also assessed. Antral follicle count (AFC) was evaluated using transvaginal ultrasound. Results The study found that patients with PCOS and SCH exhibited significantly higher levels of TSH and PRL compared to those with PCOS alone. However, there were no significant differences in PRG, LH, FSH, TES, and E2 levels between the groups. The PCOS group showed a moderate positive correlation between TSH and AMH, whereas the PCOS with SCH group demonstrated a negative correlation between TSH and FSH, albeit not statistically significant. Conclusions Subclinical hypothyroidism in women with PCOS is associated with altered thyroid–prolactin axis activity and a disrupted correlation between TSH and AMH, while gonadotropin levels and ovarian morphology appear unaffected. These findings warrant confirmation through prospective studies.https://doi.org/10.1186/s40001-025-02910-yPolycystic ovary syndromeSubclinical hypothyroidismEndocrine features |
| spellingShingle | Rui Hua Jing-Jun Li Wei Yang Yun Hua Yu-Long Ma Impact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndrome European Journal of Medical Research Polycystic ovary syndrome Subclinical hypothyroidism Endocrine features |
| title | Impact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndrome |
| title_full | Impact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndrome |
| title_fullStr | Impact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndrome |
| title_full_unstemmed | Impact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndrome |
| title_short | Impact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndrome |
| title_sort | impact of subclinical hypothyroidism on endocrine features in patients with polycystic ovary syndrome |
| topic | Polycystic ovary syndrome Subclinical hypothyroidism Endocrine features |
| url | https://doi.org/10.1186/s40001-025-02910-y |
| work_keys_str_mv | AT ruihua impactofsubclinicalhypothyroidismonendocrinefeaturesinpatientswithpolycysticovarysyndrome AT jingjunli impactofsubclinicalhypothyroidismonendocrinefeaturesinpatientswithpolycysticovarysyndrome AT weiyang impactofsubclinicalhypothyroidismonendocrinefeaturesinpatientswithpolycysticovarysyndrome AT yunhua impactofsubclinicalhypothyroidismonendocrinefeaturesinpatientswithpolycysticovarysyndrome AT yulongma impactofsubclinicalhypothyroidismonendocrinefeaturesinpatientswithpolycysticovarysyndrome |