Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality
Abstract Background The vitamin D binding protein (DBP) plays a critical role in both innate and adaptive immune systems, participating in several clinical conditions, including coronavirus disease 2019 infection severity, and mortality rate. The study aimed to investigate the correlation between rs...
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BMC
2024-12-01
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| Series: | BMC Medical Genomics |
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| Online Access: | https://doi.org/10.1186/s12920-024-02018-y |
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| author | Eman Riad Hamed Shaymaa Abdelraheem Abdelhady Shimaa A. Al-Touny Rania M. Kishk Marwa Hussein Mohamed Fatma Rageh Amira Ahmed Abdelrahman Othman Wagdy Abdelfatah Hasnaa Azab |
| author_facet | Eman Riad Hamed Shaymaa Abdelraheem Abdelhady Shimaa A. Al-Touny Rania M. Kishk Marwa Hussein Mohamed Fatma Rageh Amira Ahmed Abdelrahman Othman Wagdy Abdelfatah Hasnaa Azab |
| author_sort | Eman Riad Hamed |
| collection | DOAJ |
| description | Abstract Background The vitamin D binding protein (DBP) plays a critical role in both innate and adaptive immune systems, participating in several clinical conditions, including coronavirus disease 2019 infection severity, and mortality rate. The study aimed to investigate the correlation between rs7041 and rs4588 polymorphisms in the DBP gene and Coronavirus Disease-2019 (COVID-19) severity and mortality, in patients of Suez Canal University Hospitals in Ismailia, Egypt. Methods A case-control study enrolled 220 individuals; 140 COVID-19 patients and 80 healthy controls. Serum 25(OH) vitamin D levels were determined by the enzyme-linked immunosorbent assay (ELISA), and rs7041 and rs4588 polymorphisms of the DBP gene were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The study found that both groups had vitamin D deficiency, which was considerably lower in the COVID-19 patients group compared to controls. Among COVID-19 patients, there was a significant difference in vitamin D levels according to the disease severity indicating that vitamin D levels can be used as predictors of COVID-19 severity. Negative significant correlations between genetic variants rs4588 CA genotype and genetic variants rs7041 TT genotype and COVID-19 prevalence (p = 0.006 and 0.009 respectively) were proved. No significant correlations between all the genetic variants of both rs4588 and rs7041 and COVID-19 severity (p > 0.05). Positive significant correlations between both genetic variants rs4588 CA genotype and genetic variants rs7041 TG genotype and COVID-19 mortality (p = 0.029 and 0.031 respectively). Conclusion vitamin D deficiency increased the severity of COVID-19. The DBP polymorphism correlated with vitamin COVID-19 prevalence and mortality. |
| format | Article |
| id | doaj-art-cf82bd4857fc484cb0585eedf64c1406 |
| institution | OA Journals |
| issn | 1755-8794 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj-art-cf82bd4857fc484cb0585eedf64c14062025-08-20T02:31:05ZengBMCBMC Medical Genomics1755-87942024-12-0117111410.1186/s12920-024-02018-yCorrelation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortalityEman Riad Hamed0Shaymaa Abdelraheem Abdelhady1Shimaa A. Al-Touny2Rania M. Kishk3Marwa Hussein Mohamed4Fatma Rageh5Amira Ahmed Abdelrahman Othman6Wagdy Abdelfatah7Hasnaa Azab8Internal Medicine Department, Faculty of Medicine, Suez-Canal UniversityClinical Pathology Department, Faculty of Medicine, Suez Canal UniversityAnesthesia and Intensive Care Department, Faculty of Medicine, Suez Canal UniversityMicrobiology and Immunology Department, Faculty of Medicine, Suez Canal UniversityMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal UniversityInfectious Diseases, Gastroenterology and Hepatology Department, Faculty of Medicine, Suez UniversityInternal Medicine Department, Faculty of Medicine, Suez UniversityChest Diseases Department, Faculty of Medicine, Suez Canal UniversityMicrobiology and Immunology Department, Faculty of Medicine, Suez Canal UniversityAbstract Background The vitamin D binding protein (DBP) plays a critical role in both innate and adaptive immune systems, participating in several clinical conditions, including coronavirus disease 2019 infection severity, and mortality rate. The study aimed to investigate the correlation between rs7041 and rs4588 polymorphisms in the DBP gene and Coronavirus Disease-2019 (COVID-19) severity and mortality, in patients of Suez Canal University Hospitals in Ismailia, Egypt. Methods A case-control study enrolled 220 individuals; 140 COVID-19 patients and 80 healthy controls. Serum 25(OH) vitamin D levels were determined by the enzyme-linked immunosorbent assay (ELISA), and rs7041 and rs4588 polymorphisms of the DBP gene were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The study found that both groups had vitamin D deficiency, which was considerably lower in the COVID-19 patients group compared to controls. Among COVID-19 patients, there was a significant difference in vitamin D levels according to the disease severity indicating that vitamin D levels can be used as predictors of COVID-19 severity. Negative significant correlations between genetic variants rs4588 CA genotype and genetic variants rs7041 TT genotype and COVID-19 prevalence (p = 0.006 and 0.009 respectively) were proved. No significant correlations between all the genetic variants of both rs4588 and rs7041 and COVID-19 severity (p > 0.05). Positive significant correlations between both genetic variants rs4588 CA genotype and genetic variants rs7041 TG genotype and COVID-19 mortality (p = 0.029 and 0.031 respectively). Conclusion vitamin D deficiency increased the severity of COVID-19. The DBP polymorphism correlated with vitamin COVID-19 prevalence and mortality.https://doi.org/10.1186/s12920-024-02018-yCOVID-19DBPPolymorphismrs4588rs7041Vitamin D binding protein |
| spellingShingle | Eman Riad Hamed Shaymaa Abdelraheem Abdelhady Shimaa A. Al-Touny Rania M. Kishk Marwa Hussein Mohamed Fatma Rageh Amira Ahmed Abdelrahman Othman Wagdy Abdelfatah Hasnaa Azab Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality BMC Medical Genomics COVID-19 DBP Polymorphism rs4588 rs7041 Vitamin D binding protein |
| title | Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality |
| title_full | Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality |
| title_fullStr | Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality |
| title_full_unstemmed | Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality |
| title_short | Correlation between rs7041 and rs4588 polymorphisms in vitamin D binding protein gene and COVID-19-related severity and mortality |
| title_sort | correlation between rs7041 and rs4588 polymorphisms in vitamin d binding protein gene and covid 19 related severity and mortality |
| topic | COVID-19 DBP Polymorphism rs4588 rs7041 Vitamin D binding protein |
| url | https://doi.org/10.1186/s12920-024-02018-y |
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