SLC19A1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a common pediatric malignancy. Methotrexate is the widely used chemotherapy for ALL. The polymorphism (rs1051296) of SLC19A1 is proposed for its effect on serum methotrexate. To explain this observation, the authors hereby studied the interrelationship between S...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2018-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=1;spage=120;epage=121;aulast=Joob |
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| _version_ | 1849768371889897472 |
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| author | Beuy Joob Viroj Wiwanitkit |
| author_facet | Beuy Joob Viroj Wiwanitkit |
| author_sort | Beuy Joob |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) is a common pediatric malignancy. Methotrexate is the widely used chemotherapy for ALL. The polymorphism (rs1051296) of SLC19A1 is proposed for its effect on serum methotrexate. To explain this observation, the authors hereby studied the interrelationship between SLC19A1 polymorphism and blood methotrexate level in the patients with ALL. Here, the authors use a quantum chemistry analysis for explaining of this observation. |
| format | Article |
| id | doaj-art-cf762a1add004e61bb47c1b8bcc474c3 |
| institution | DOAJ |
| issn | 0971-5851 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-cf762a1add004e61bb47c1b8bcc474c32025-08-20T03:03:50ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512018-01-0139112012110.4103/ijmpo.ijmpo_6_16SLC19A1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemiaBeuy JoobViroj WiwanitkitAcute lymphoblastic leukemia (ALL) is a common pediatric malignancy. Methotrexate is the widely used chemotherapy for ALL. The polymorphism (rs1051296) of SLC19A1 is proposed for its effect on serum methotrexate. To explain this observation, the authors hereby studied the interrelationship between SLC19A1 polymorphism and blood methotrexate level in the patients with ALL. Here, the authors use a quantum chemistry analysis for explaining of this observation.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=1;spage=120;epage=121;aulast=JoobAcute lymphoblastic leukemiamethotrexatepolymorphism |
| spellingShingle | Beuy Joob Viroj Wiwanitkit SLC19A1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemia Indian Journal of Medical and Paediatric Oncology Acute lymphoblastic leukemia methotrexate polymorphism |
| title | SLC19A1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemia |
| title_full | SLC19A1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemia |
| title_fullStr | SLC19A1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemia |
| title_full_unstemmed | SLC19A1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemia |
| title_short | SLC19A1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemia |
| title_sort | slc19a1 polymorphism and serum methotrexate in patients with acute lymphoblastic leukemia |
| topic | Acute lymphoblastic leukemia methotrexate polymorphism |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=1;spage=120;epage=121;aulast=Joob |
| work_keys_str_mv | AT beuyjoob slc19a1polymorphismandserummethotrexateinpatientswithacutelymphoblasticleukemia AT virojwiwanitkit slc19a1polymorphismandserummethotrexateinpatientswithacutelymphoblasticleukemia |