Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure
Aim. To study the role of plasma redox potential reduction in the development of endothelial dysfunction (ED) among patients with chronic heart failure (CHF) and to investigate the potential of its pharmacological correction. Material and methods. This randomised cohort study included 73 patients wi...
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| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2012-02-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1699 |
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| author | O. P. Donetskaya V. A. Tulupova N. V. Shuldeshova M. M. Fedorova |
| author_facet | O. P. Donetskaya V. A. Tulupova N. V. Shuldeshova M. M. Fedorova |
| author_sort | O. P. Donetskaya |
| collection | DOAJ |
| description | Aim. To study the role of plasma redox potential reduction in the development of endothelial dysfunction (ED) among patients with chronic heart failure (CHF) and to investigate the potential of its pharmacological correction. Material and methods. This randomised cohort study included 73 patients with CHF, due to coronary heart disease (CHD) and arterial hypertension. Mean age of the participants was 59,2±5,9 years. Functional Class (FC) I CHF was registered in 9 patients, FC II CHF in 21, FC III CHF in 23, and FC IV CHF in 11. After the baseline examination, all participants were randomised into two groups. The main group (MG) received standard therapy plus adenocin (2 ampoules in 70 ml 5% glucose, intravenously) for 10 days. Results. For the first time, the dynamics of redox potential and total pyridine nucleotide levels was assessed in relation to the FC of ischemic CHF. Redox potential reduction preceded the changes in the total pyridine nucleotide levels. In contrast to standard therapy, adenocin increased plasma redox potential and endothelial growth factor levels, while reducing endothelin-1 concentrations and NADPH oxidase activity. Conclusion. Combination therapy with adenocin – a unique medication of reduced NAD form, cardiac glycoside, and inosine, in contrast to standard treatment, significantly increased cellular redox potential in CHF, which could play an important role in angiogenesis stimulation and reverse endothelial remodelling. |
| format | Article |
| id | doaj-art-cf72dd3620d5481aa91f2d9bc86ffedb |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2012-02-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-cf72dd3620d5481aa91f2d9bc86ffedb2025-08-20T03:35:47Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252012-02-01111545810.15829/1728-8800-2012-1-54-581417Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failureO. P. Donetskaya0V. A. Tulupova1N. V. Shuldeshova2M. M. Fedorova3Clinical Hospital No. 1, Russian Federation President’s Administration, MoscowClinical Hospital No. 1, Russian Federation President’s Administration, MoscowClinical Hospital No. 1, Russian Federation President’s Administration, MoscowRussian Medical Academy of Post-Diploma Education, MoscowAim. To study the role of plasma redox potential reduction in the development of endothelial dysfunction (ED) among patients with chronic heart failure (CHF) and to investigate the potential of its pharmacological correction. Material and methods. This randomised cohort study included 73 patients with CHF, due to coronary heart disease (CHD) and arterial hypertension. Mean age of the participants was 59,2±5,9 years. Functional Class (FC) I CHF was registered in 9 patients, FC II CHF in 21, FC III CHF in 23, and FC IV CHF in 11. After the baseline examination, all participants were randomised into two groups. The main group (MG) received standard therapy plus adenocin (2 ampoules in 70 ml 5% glucose, intravenously) for 10 days. Results. For the first time, the dynamics of redox potential and total pyridine nucleotide levels was assessed in relation to the FC of ischemic CHF. Redox potential reduction preceded the changes in the total pyridine nucleotide levels. In contrast to standard therapy, adenocin increased plasma redox potential and endothelial growth factor levels, while reducing endothelin-1 concentrations and NADPH oxidase activity. Conclusion. Combination therapy with adenocin – a unique medication of reduced NAD form, cardiac glycoside, and inosine, in contrast to standard treatment, significantly increased cellular redox potential in CHF, which could play an important role in angiogenesis stimulation and reverse endothelial remodelling.https://cardiovascular.elpub.ru/jour/article/view/1699coronary heart diseaseheart failureredox potentialendothelial dysfunctionadenocinnicotinamide adenine dinucleotide |
| spellingShingle | O. P. Donetskaya V. A. Tulupova N. V. Shuldeshova M. M. Fedorova Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure Кардиоваскулярная терапия и профилактика coronary heart disease heart failure redox potential endothelial dysfunction adenocin nicotinamide adenine dinucleotide |
| title | Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure |
| title_full | Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure |
| title_fullStr | Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure |
| title_full_unstemmed | Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure |
| title_short | Pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure |
| title_sort | pharmacological correction of plasma redox potential and endothelial dysfunction in ischemic heart failure |
| topic | coronary heart disease heart failure redox potential endothelial dysfunction adenocin nicotinamide adenine dinucleotide |
| url | https://cardiovascular.elpub.ru/jour/article/view/1699 |
| work_keys_str_mv | AT opdonetskaya pharmacologicalcorrectionofplasmaredoxpotentialandendothelialdysfunctioninischemicheartfailure AT vatulupova pharmacologicalcorrectionofplasmaredoxpotentialandendothelialdysfunctioninischemicheartfailure AT nvshuldeshova pharmacologicalcorrectionofplasmaredoxpotentialandendothelialdysfunctioninischemicheartfailure AT mmfedorova pharmacologicalcorrectionofplasmaredoxpotentialandendothelialdysfunctioninischemicheartfailure |