Quantitative analysis of regulatory flexibility under changing environmental conditions
Abstract The circadian clock controls 24‐h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops. Theory suggested that multiple loops contribute the flexibility for molecul...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2010-11-01
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| Series: | Molecular Systems Biology |
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| Online Access: | https://doi.org/10.1038/msb.2010.81 |
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| _version_ | 1849225797378768896 |
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| author | Kieron D Edwards Ozgur E Akman Kirsten Knox Peter J Lumsden Adrian W Thomson Paul E Brown Alexandra Pokhilko Laszlo Kozma‐Bognar Ferenc Nagy David A Rand Andrew J Millar |
| author_facet | Kieron D Edwards Ozgur E Akman Kirsten Knox Peter J Lumsden Adrian W Thomson Paul E Brown Alexandra Pokhilko Laszlo Kozma‐Bognar Ferenc Nagy David A Rand Andrew J Millar |
| author_sort | Kieron D Edwards |
| collection | DOAJ |
| description | Abstract The circadian clock controls 24‐h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops. Theory suggested that multiple loops contribute the flexibility for molecular rhythms to track multiple phases of the external cycle. Clear dawn‐ and dusk‐tracking rhythms illustrate the flexibility of timing in Ipomoea nil. Molecular clock components in Arabidopsis thaliana showed complex, photoperiod‐dependent regulation, which was analysed by comparison with three contrasting models. A simple, quantitative measure, Dusk Sensitivity, was introduced to compare the behaviour of clock models with varying loop complexity. Evening‐expressed clock genes showed photoperiod‐dependent dusk sensitivity, as predicted by the three‐loop model, whereas the one‐ and two‐loop models tracked dawn and dusk, respectively. Output genes for starch degradation achieved dusk‐tracking expression through light regulation, rather than a dusk‐tracking rhythm. Model analysis predicted which biochemical processes could be manipulated to extend dusk tracking. Our results reveal how an operating principle of biological regulators applies specifically to the plant circadian clock. |
| format | Article |
| id | doaj-art-cf71725a5e234aefa766d930f55e26a4 |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2010-11-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-cf71725a5e234aefa766d930f55e26a42025-08-24T12:00:46ZengSpringer NatureMolecular Systems Biology1744-42922010-11-016111110.1038/msb.2010.81Quantitative analysis of regulatory flexibility under changing environmental conditionsKieron D Edwards0Ozgur E Akman1Kirsten Knox2Peter J Lumsden3Adrian W Thomson4Paul E Brown5Alexandra Pokhilko6Laszlo Kozma‐Bognar7Ferenc Nagy8David A Rand9Andrew J Millar10School of Biological Sciences, University of EdinburghCentre for Systems Biology at EdinburghSchool of Biological Sciences, University of EdinburghUniversity of Central LancashireSchool of Biological Sciences, University of EdinburghWarwick Systems Biology Centre, University of WarwickSchool of Biological Sciences, University of EdinburghBiological Research Centre of the Hungarian Academy of SciencesSchool of Biological Sciences, University of EdinburghWarwick Systems Biology Centre, University of WarwickSchool of Biological Sciences, University of EdinburghAbstract The circadian clock controls 24‐h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops. Theory suggested that multiple loops contribute the flexibility for molecular rhythms to track multiple phases of the external cycle. Clear dawn‐ and dusk‐tracking rhythms illustrate the flexibility of timing in Ipomoea nil. Molecular clock components in Arabidopsis thaliana showed complex, photoperiod‐dependent regulation, which was analysed by comparison with three contrasting models. A simple, quantitative measure, Dusk Sensitivity, was introduced to compare the behaviour of clock models with varying loop complexity. Evening‐expressed clock genes showed photoperiod‐dependent dusk sensitivity, as predicted by the three‐loop model, whereas the one‐ and two‐loop models tracked dawn and dusk, respectively. Output genes for starch degradation achieved dusk‐tracking expression through light regulation, rather than a dusk‐tracking rhythm. Model analysis predicted which biochemical processes could be manipulated to extend dusk tracking. Our results reveal how an operating principle of biological regulators applies specifically to the plant circadian clock.https://doi.org/10.1038/msb.2010.81Arabidopsis thalianabiological clocksdynamical systemsgene regulatory networksmathematical modelsphotoperiodism |
| spellingShingle | Kieron D Edwards Ozgur E Akman Kirsten Knox Peter J Lumsden Adrian W Thomson Paul E Brown Alexandra Pokhilko Laszlo Kozma‐Bognar Ferenc Nagy David A Rand Andrew J Millar Quantitative analysis of regulatory flexibility under changing environmental conditions Molecular Systems Biology Arabidopsis thaliana biological clocks dynamical systems gene regulatory networks mathematical models photoperiodism |
| title | Quantitative analysis of regulatory flexibility under changing environmental conditions |
| title_full | Quantitative analysis of regulatory flexibility under changing environmental conditions |
| title_fullStr | Quantitative analysis of regulatory flexibility under changing environmental conditions |
| title_full_unstemmed | Quantitative analysis of regulatory flexibility under changing environmental conditions |
| title_short | Quantitative analysis of regulatory flexibility under changing environmental conditions |
| title_sort | quantitative analysis of regulatory flexibility under changing environmental conditions |
| topic | Arabidopsis thaliana biological clocks dynamical systems gene regulatory networks mathematical models photoperiodism |
| url | https://doi.org/10.1038/msb.2010.81 |
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