Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus
The hippocampus has the extraordinary capacity to process and store information. Consequently, there is an intense interest in the mechanisms that underline learning and memory. Synaptic plasticity has been hypothesized to be the neuronal substrate for learning. Ca2+ and Ca2+-activated kinases contr...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/945373 |
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| _version_ | 1832553638110691328 |
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| author | Masako Isokawa |
| author_facet | Masako Isokawa |
| author_sort | Masako Isokawa |
| collection | DOAJ |
| description | The hippocampus has the extraordinary capacity to process and store information. Consequently, there is an intense interest in the mechanisms that underline learning and memory. Synaptic plasticity has been hypothesized to be the neuronal substrate for learning. Ca2+ and Ca2+-activated kinases control cellular processes of most forms of hippocampal synapse plasticity. In this paper, I aim to integrate our current understanding of Ca2+-mediated synaptic plasticity and metaplasticity in motivational and reward-related learning in the hippocampus. I will introduce two representative neuromodulators that are widely studied in reward-related learning (e.g., ghrelin and endocannabinoids) and show how they might contribute to hippocampal neuron activities and Ca2+-mediated signaling processes in synaptic plasticity. Additionally, I will discuss functional significance of these two systems and their signaling pathways for its relevance to maladaptive reward learning leading to addiction. |
| format | Article |
| id | doaj-art-cf7158ec54654a579a8dedf20859707e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-cf7158ec54654a579a8dedf20859707e2025-02-03T05:53:41ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/945373945373Cellular Signal Mechanisms of Reward-Related Plasticity in the HippocampusMasako Isokawa0Department of Biomedicine, College of Biomedical Sciences and Health Professions, The University of Texas at Brownsville, 80 Fort Brown, Brownsville, TX 78520, USAThe hippocampus has the extraordinary capacity to process and store information. Consequently, there is an intense interest in the mechanisms that underline learning and memory. Synaptic plasticity has been hypothesized to be the neuronal substrate for learning. Ca2+ and Ca2+-activated kinases control cellular processes of most forms of hippocampal synapse plasticity. In this paper, I aim to integrate our current understanding of Ca2+-mediated synaptic plasticity and metaplasticity in motivational and reward-related learning in the hippocampus. I will introduce two representative neuromodulators that are widely studied in reward-related learning (e.g., ghrelin and endocannabinoids) and show how they might contribute to hippocampal neuron activities and Ca2+-mediated signaling processes in synaptic plasticity. Additionally, I will discuss functional significance of these two systems and their signaling pathways for its relevance to maladaptive reward learning leading to addiction.http://dx.doi.org/10.1155/2012/945373 |
| spellingShingle | Masako Isokawa Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus Neural Plasticity |
| title | Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus |
| title_full | Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus |
| title_fullStr | Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus |
| title_full_unstemmed | Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus |
| title_short | Cellular Signal Mechanisms of Reward-Related Plasticity in the Hippocampus |
| title_sort | cellular signal mechanisms of reward related plasticity in the hippocampus |
| url | http://dx.doi.org/10.1155/2012/945373 |
| work_keys_str_mv | AT masakoisokawa cellularsignalmechanismsofrewardrelatedplasticityinthehippocampus |