Microbiota Modulation to Improve estimated Glomerular Filtration Rate, Uremic Toxins, and Inflammatory Marker in Chronic Kidney Disease: Systematic Review and Meta-Analysis
Introduction. Dysbiosis microbiota is considered as one of the consequences and impacts of high uremic toxins in patients with Chronic Kidney Disease (CKD), which can lead to an increased risk of progression and mortality. The aim of this systematic review and meta-analysis was to perform quantitati...
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2023-03-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
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| Online Access: | https://scholarhub.ui.ac.id/jpdi/vol10/iss1/5/ |
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| author | Burhan Gunawan Raymond Sebastian Purwata Syarif Hidayat Roy Akur Pandapotan Jennifer |
| author_facet | Burhan Gunawan Raymond Sebastian Purwata Syarif Hidayat Roy Akur Pandapotan Jennifer |
| author_sort | Burhan Gunawan |
| collection | DOAJ |
| description | Introduction. Dysbiosis microbiota is considered as one of the consequences and impacts of high uremic toxins in patients with Chronic Kidney Disease (CKD), which can lead to an increased risk of progression and mortality. The aim of this systematic review and meta-analysis was to perform quantitative effect of microbiota modulation for estimated Glomerular Filtration Rate (eGFR), uremic toxin (total-p cresyl/total pCS), and inflammatory marker (hs-CRP) outcome among CKD patients.
Methods. Article searches were conducted from PubMed, ScienceDirect, and Cochrane Library data sources from 2010-2022. Assessment of article quality follows the rules of PRISMA (Preferred Reporting Items in Systematic Review and Meta-Analysis). Only randomized controlled trial (RCT) articles investigating the effect of symbiotic, prebiotic, of probiotic for CKD were included in the analysis. Effect size quantify from Standardized Mean Difference (SMD), using a continuous random effect model and described in the forest plot model.
Results. A total of 17 RCT studies with a total 867 CKD stage 1-5 subjects (440 subjects in the intervention group and 427 subjects in the control group). The intervention duration ranging from 1-12 months. The studies included had varied on methodologies, with significant heterogenicity (I296,96%, p
Conclusions. The administration of probiotic/prebiotic/symbiotic supplements to CKD patients resulted in significant improvements in e-GFR and reductions in total pCS. These results suggest the potential of symbiotic, prebiotic, and probiotic supplementation to improve CKD outcome. |
| format | Article |
| id | doaj-art-cf6980dfd5fd425ab9dd2403e64762a6 |
| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2023-03-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-cf6980dfd5fd425ab9dd2403e64762a62025-08-20T02:01:09ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212023-03-011012532https://doi.org/10.7454/jpdi.v10i1.1036Microbiota Modulation to Improve estimated Glomerular Filtration Rate, Uremic Toxins, and Inflammatory Marker in Chronic Kidney Disease: Systematic Review and Meta-AnalysisBurhan Gunawan0Raymond Sebastian Purwata 1Syarif Hidayat 2Roy Akur Pandapotan 3Jennifer 4Divisi Ilmu Penyakit Dalam, Rumah Sakit Sumber Waras, Jakarta Barat, IndonesiaDivisi Ilmu Penyakit Dalam, Rumah Sakit Sumber Waras, Jakarta Barat, Indonesia Divisi Ilmu Penyakit Dalam, Rumah Sakit Sumber Waras, Jakarta Barat, IndonesiaDivisi Ilmu Penyakit Dalam, Rumah Sakit Sumber Waras, Jakarta Barat, Indonesia Divisi Ilmu Penyakit Dalam, Rumah Sakit Sumber Waras, Jakarta Barat, IndonesiaIntroduction. Dysbiosis microbiota is considered as one of the consequences and impacts of high uremic toxins in patients with Chronic Kidney Disease (CKD), which can lead to an increased risk of progression and mortality. The aim of this systematic review and meta-analysis was to perform quantitative effect of microbiota modulation for estimated Glomerular Filtration Rate (eGFR), uremic toxin (total-p cresyl/total pCS), and inflammatory marker (hs-CRP) outcome among CKD patients. Methods. Article searches were conducted from PubMed, ScienceDirect, and Cochrane Library data sources from 2010-2022. Assessment of article quality follows the rules of PRISMA (Preferred Reporting Items in Systematic Review and Meta-Analysis). Only randomized controlled trial (RCT) articles investigating the effect of symbiotic, prebiotic, of probiotic for CKD were included in the analysis. Effect size quantify from Standardized Mean Difference (SMD), using a continuous random effect model and described in the forest plot model. Results. A total of 17 RCT studies with a total 867 CKD stage 1-5 subjects (440 subjects in the intervention group and 427 subjects in the control group). The intervention duration ranging from 1-12 months. The studies included had varied on methodologies, with significant heterogenicity (I296,96%, p Conclusions. The administration of probiotic/prebiotic/symbiotic supplements to CKD patients resulted in significant improvements in e-GFR and reductions in total pCS. These results suggest the potential of symbiotic, prebiotic, and probiotic supplementation to improve CKD outcome.https://scholarhub.ui.ac.id/jpdi/vol10/iss1/5/chronic kidney diseasee-gfrhs-crpprebioticprobioticuremic toxin |
| spellingShingle | Burhan Gunawan Raymond Sebastian Purwata Syarif Hidayat Roy Akur Pandapotan Jennifer Microbiota Modulation to Improve estimated Glomerular Filtration Rate, Uremic Toxins, and Inflammatory Marker in Chronic Kidney Disease: Systematic Review and Meta-Analysis Jurnal Penyakit Dalam Indonesia chronic kidney disease e-gfr hs-crp prebiotic probiotic uremic toxin |
| title | Microbiota Modulation to Improve estimated Glomerular Filtration Rate, Uremic Toxins, and Inflammatory Marker in Chronic Kidney Disease: Systematic Review and Meta-Analysis |
| title_full | Microbiota Modulation to Improve estimated Glomerular Filtration Rate, Uremic Toxins, and Inflammatory Marker in Chronic Kidney Disease: Systematic Review and Meta-Analysis |
| title_fullStr | Microbiota Modulation to Improve estimated Glomerular Filtration Rate, Uremic Toxins, and Inflammatory Marker in Chronic Kidney Disease: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Microbiota Modulation to Improve estimated Glomerular Filtration Rate, Uremic Toxins, and Inflammatory Marker in Chronic Kidney Disease: Systematic Review and Meta-Analysis |
| title_short | Microbiota Modulation to Improve estimated Glomerular Filtration Rate, Uremic Toxins, and Inflammatory Marker in Chronic Kidney Disease: Systematic Review and Meta-Analysis |
| title_sort | microbiota modulation to improve estimated glomerular filtration rate uremic toxins and inflammatory marker in chronic kidney disease systematic review and meta analysis |
| topic | chronic kidney disease e-gfr hs-crp prebiotic probiotic uremic toxin |
| url | https://scholarhub.ui.ac.id/jpdi/vol10/iss1/5/ |
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