Iron overload mediates cytarabine resistance in AML by inhibiting the TP53 signaling pathway

Iron overload mediates cytarabine resistance in AML by inhibiting the TP53 signaling pathway

Currently, chemotherapy remains the primary treatment for acute myeloid leukemia (AML). Drug resistance in AML cells is a critical factor contributing to the failure of chemotherapy remission and subsequent relapse. Iron overload frequently...

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Bibliographic Details
Main Authors: Jia Yan, Li Ling, Li Ying, Zhu Xunxun, Wang Haiyan, Xu Bin, Li Qiuping, Zhang Hao
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2025-02-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
acute myeloid leukemia
TP53
iron overload
TFR1
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2025027
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