Sterile osteomyelitis: a cardinal sign of autoinflammation
Autoinflammatory bone disorders (ABDs) are characterized by sterile bone inflammation stemming from dysregulated innate immune responses. This review focuses on the occurrence of sterile osteomyelitis in ABDs and related diseases, notably chronic nonbacterial osteomyelitis (CNO) and its sporadic an...
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Termedia Publishing House
2024-12-01
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| Series: | Rheumatology |
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| Online Access: | https://reu.termedia.pl/Sterile-osteomyelitis-a-cardinal-sign-of-autoinflammation,196595,0,2.html |
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| author | Tiago Borges João Santos Sérgio Silva |
| author_facet | Tiago Borges João Santos Sérgio Silva |
| author_sort | Tiago Borges |
| collection | DOAJ |
| description | Autoinflammatory bone disorders (ABDs) are characterized by sterile bone inflammation stemming from dysregulated innate immune responses. This review focuses on the occurrence of sterile osteomyelitis in ABDs and related diseases, notably chronic nonbacterial osteomyelitis (CNO) and its sporadic and monogenic forms, such as deficiency of the interleukin-1 (IL-1) receptor antagonist, Majeed syndrome, CNO related to FBLIM1 mutation, and pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA syndrome). Additionally, other autoinflammatory disorders (AIDs) are discussed, including classical periodic fever syndromes (e.g., familial Mediterranean fever, cryopyrin- associated periodic syndromes), monogenic rare AIDs (such as hyperostosis-hyperphosphatemia syndrome, H syndrome, interferonopathies, and Singleton-Merten’s syndrome), polygenic AIDs with bone involvement (e.g., Schnitzler’s syndrome, systemic juvenile idiopathic arthritis, adult-onset Still’s disease, and calcium pyrophosphate deposition disease), and bone dysplastic syndromes. Sterile osteomyelitis emerges as a cardinal sign of autoinflammation, aiding clinicians in both diagnosis and management of ABDs. Treatment typically involves tumor necrosis factor inhibitors or IL-1 antagonists. |
| format | Article |
| id | doaj-art-cf605704aecd4825965855a0e6730c8c |
| institution | Kabale University |
| issn | 0034-6233 2084-9834 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj-art-cf605704aecd4825965855a0e6730c8c2025-01-27T11:21:27ZengTermedia Publishing HouseRheumatology0034-62332084-98342024-12-0162647548810.5114/reum/196595196595Sterile osteomyelitis: a cardinal sign of autoinflammationTiago Borges0https://orcid.org/0000-0002-8271-9865João Santos1Sérgio Silva2https://orcid.org/0000-0002-7073-1867Department of Internal Medicine, Trofa Saúde Hospital Privado em Gaia, Vila Nova de Gaia, PortugalUSF BarcelSaúde, Barcelos, PortugalDepartment of Internal Medicine, Trofa Saúde Hospital Privado em Gaia, Vila Nova de Gaia, PortugalAutoinflammatory bone disorders (ABDs) are characterized by sterile bone inflammation stemming from dysregulated innate immune responses. This review focuses on the occurrence of sterile osteomyelitis in ABDs and related diseases, notably chronic nonbacterial osteomyelitis (CNO) and its sporadic and monogenic forms, such as deficiency of the interleukin-1 (IL-1) receptor antagonist, Majeed syndrome, CNO related to FBLIM1 mutation, and pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA syndrome). Additionally, other autoinflammatory disorders (AIDs) are discussed, including classical periodic fever syndromes (e.g., familial Mediterranean fever, cryopyrin- associated periodic syndromes), monogenic rare AIDs (such as hyperostosis-hyperphosphatemia syndrome, H syndrome, interferonopathies, and Singleton-Merten’s syndrome), polygenic AIDs with bone involvement (e.g., Schnitzler’s syndrome, systemic juvenile idiopathic arthritis, adult-onset Still’s disease, and calcium pyrophosphate deposition disease), and bone dysplastic syndromes. Sterile osteomyelitis emerges as a cardinal sign of autoinflammation, aiding clinicians in both diagnosis and management of ABDs. Treatment typically involves tumor necrosis factor inhibitors or IL-1 antagonists.https://reu.termedia.pl/Sterile-osteomyelitis-a-cardinal-sign-of-autoinflammation,196595,0,2.htmlinnate immunityosteomyelitischronic recurrent multifocal osteomyelitis |
| spellingShingle | Tiago Borges João Santos Sérgio Silva Sterile osteomyelitis: a cardinal sign of autoinflammation Rheumatology innate immunity osteomyelitis chronic recurrent multifocal osteomyelitis |
| title | Sterile osteomyelitis: a cardinal sign of autoinflammation |
| title_full | Sterile osteomyelitis: a cardinal sign of autoinflammation |
| title_fullStr | Sterile osteomyelitis: a cardinal sign of autoinflammation |
| title_full_unstemmed | Sterile osteomyelitis: a cardinal sign of autoinflammation |
| title_short | Sterile osteomyelitis: a cardinal sign of autoinflammation |
| title_sort | sterile osteomyelitis a cardinal sign of autoinflammation |
| topic | innate immunity osteomyelitis chronic recurrent multifocal osteomyelitis |
| url | https://reu.termedia.pl/Sterile-osteomyelitis-a-cardinal-sign-of-autoinflammation,196595,0,2.html |
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