Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent
The acid dissociation constants of potential bioactive fused ring thiohydantoin-pyrrolidine compounds were determined by potentiometric titration in 20% (v/v) ethanol-water mixed at 25±0.1°C, at an ionic background of 0.1 mol/L of NaCl using the HYPERQUAD computer program. Proton affinities of pote...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/634194 |
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| author | Yahya Nural H. Ali Döndaş Hayati Sarı Hasan Atabey Samet Belveren Müge Gemili |
| author_facet | Yahya Nural H. Ali Döndaş Hayati Sarı Hasan Atabey Samet Belveren Müge Gemili |
| author_sort | Yahya Nural |
| collection | DOAJ |
| description | The acid dissociation constants of potential bioactive fused ring thiohydantoin-pyrrolidine compounds were determined by potentiometric titration in 20% (v/v) ethanol-water mixed at 25±0.1°C, at an ionic background of 0.1 mol/L of NaCl using the HYPERQUAD computer program. Proton affinities of potential donor atoms of the ligands were calculated by AM1 and PM3 semiempiric methods. We found, potentiometrically, three different acid dissociation constants for 1a–f. We suggest that these acid dissociation constants are related to the carboxyl, enol, and amino groups. |
| format | Article |
| id | doaj-art-cf602304982147cab799289b906c3493 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-cf602304982147cab799289b906c34932025-02-03T06:13:51ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792014-01-01201410.1155/2014/634194634194Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic SolventYahya Nural0H. Ali Döndaş1Hayati Sarı2Hasan Atabey3Samet Belveren4Müge Gemili5Department of Chemistry, Faculty of Pharmacy, Mersin University, 33169 Mersin, TurkeyDepartment of Chemistry, Faculty of Pharmacy, Mersin University, 33169 Mersin, TurkeyDepartment of Chemistry, Faculty of Science and Arts, Gaziosmanpasa University, 60250 Tokat, TurkeyDepartment of Chemistry, Faculty of Science and Arts, Gaziosmanpasa University, 60250 Tokat, TurkeyDepartment of Chemistry, Faculty of Pharmacy, Mersin University, 33169 Mersin, TurkeyDepartment of Chemistry, Faculty of Pharmacy, Mersin University, 33169 Mersin, TurkeyThe acid dissociation constants of potential bioactive fused ring thiohydantoin-pyrrolidine compounds were determined by potentiometric titration in 20% (v/v) ethanol-water mixed at 25±0.1°C, at an ionic background of 0.1 mol/L of NaCl using the HYPERQUAD computer program. Proton affinities of potential donor atoms of the ligands were calculated by AM1 and PM3 semiempiric methods. We found, potentiometrically, three different acid dissociation constants for 1a–f. We suggest that these acid dissociation constants are related to the carboxyl, enol, and amino groups.http://dx.doi.org/10.1155/2014/634194 |
| spellingShingle | Yahya Nural H. Ali Döndaş Hayati Sarı Hasan Atabey Samet Belveren Müge Gemili Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent International Journal of Analytical Chemistry |
| title | Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent |
| title_full | Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent |
| title_fullStr | Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent |
| title_full_unstemmed | Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent |
| title_short | Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent |
| title_sort | determination of acid dissociation constants pka of bicyclic thiohydantoin pyrrolidine compounds in 20 ethanol water hydroorganic solvent |
| url | http://dx.doi.org/10.1155/2014/634194 |
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