Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome
Background. Autoimmune/inflammatory syndrome induced by adjuvants is a disease associated with an unregulated hyperactivity of the immune system and may also be associated with a high frequency of hematologic malignancies. Report. This is a case of a female with ASIA-MO syndrome secondary to infiltr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/8571536 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553637877907456 |
|---|---|
| author | David Alejandro Vargas Gutiérrez Karina Ivonne Arias Callejas Edwin Pavel Palacios Ruiz Priscila Joseline Pérez Vinueza Juan Diego Muñoz Vega Ana Karen G. Mejía Geraldo Ingrid Salinas Zaldívar |
| author_facet | David Alejandro Vargas Gutiérrez Karina Ivonne Arias Callejas Edwin Pavel Palacios Ruiz Priscila Joseline Pérez Vinueza Juan Diego Muñoz Vega Ana Karen G. Mejía Geraldo Ingrid Salinas Zaldívar |
| author_sort | David Alejandro Vargas Gutiérrez |
| collection | DOAJ |
| description | Background. Autoimmune/inflammatory syndrome induced by adjuvants is a disease associated with an unregulated hyperactivity of the immune system and may also be associated with a high frequency of hematologic malignancies. Report. This is a case of a female with ASIA-MO syndrome secondary to infiltration of mineral oil for aesthetic purposes and presented with multiple episodes of urolithiasis resulting in renal impairment of her left kidney confirmed by scintigraphy and ending in unilateral nephrectomy. Retrospective renal piece analysis confirmed tubulointerstitial infiltration with light chains and plasma cells. Paraffin fixation prevented subsequent immunofluorescence analysis for better follow-up of the patient. Conclusion. The presence of positive immunofixation kappa chains explained the sudden deterioration of renal function with monoclonal gammopathy of renal significance which concluded in an association between diseases, such as multiple light chain myeloma, as a final diagnosis. |
| format | Article |
| id | doaj-art-cf5a6167b54b48ca9672b1e49ee5f842 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-cf5a6167b54b48ca9672b1e49ee5f8422025-02-03T05:53:39ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/8571536Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO SyndromeDavid Alejandro Vargas Gutiérrez0Karina Ivonne Arias Callejas1Edwin Pavel Palacios Ruiz2Priscila Joseline Pérez Vinueza3Juan Diego Muñoz Vega4Ana Karen G. Mejía Geraldo5Ingrid Salinas Zaldívar6Department of RheumatologyDepartment of RheumatologyDepartment of Internal MedicineDepartment of RheumatologyDepartment of HematologyDepartment of Pathological AnatomyDepartment of Internal MedicineBackground. Autoimmune/inflammatory syndrome induced by adjuvants is a disease associated with an unregulated hyperactivity of the immune system and may also be associated with a high frequency of hematologic malignancies. Report. This is a case of a female with ASIA-MO syndrome secondary to infiltration of mineral oil for aesthetic purposes and presented with multiple episodes of urolithiasis resulting in renal impairment of her left kidney confirmed by scintigraphy and ending in unilateral nephrectomy. Retrospective renal piece analysis confirmed tubulointerstitial infiltration with light chains and plasma cells. Paraffin fixation prevented subsequent immunofluorescence analysis for better follow-up of the patient. Conclusion. The presence of positive immunofixation kappa chains explained the sudden deterioration of renal function with monoclonal gammopathy of renal significance which concluded in an association between diseases, such as multiple light chain myeloma, as a final diagnosis.http://dx.doi.org/10.1155/2022/8571536 |
| spellingShingle | David Alejandro Vargas Gutiérrez Karina Ivonne Arias Callejas Edwin Pavel Palacios Ruiz Priscila Joseline Pérez Vinueza Juan Diego Muñoz Vega Ana Karen G. Mejía Geraldo Ingrid Salinas Zaldívar Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome Case Reports in Hematology |
| title | Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome |
| title_full | Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome |
| title_fullStr | Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome |
| title_full_unstemmed | Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome |
| title_short | Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome |
| title_sort | monoclonal gammopathy of renal significance with progression to multiple myeloma in a patient with asia mo syndrome |
| url | http://dx.doi.org/10.1155/2022/8571536 |
| work_keys_str_mv | AT davidalejandrovargasgutierrez monoclonalgammopathyofrenalsignificancewithprogressiontomultiplemyelomainapatientwithasiamosyndrome AT karinaivonneariascallejas monoclonalgammopathyofrenalsignificancewithprogressiontomultiplemyelomainapatientwithasiamosyndrome AT edwinpavelpalaciosruiz monoclonalgammopathyofrenalsignificancewithprogressiontomultiplemyelomainapatientwithasiamosyndrome AT priscilajoselineperezvinueza monoclonalgammopathyofrenalsignificancewithprogressiontomultiplemyelomainapatientwithasiamosyndrome AT juandiegomunozvega monoclonalgammopathyofrenalsignificancewithprogressiontomultiplemyelomainapatientwithasiamosyndrome AT anakarengmejiageraldo monoclonalgammopathyofrenalsignificancewithprogressiontomultiplemyelomainapatientwithasiamosyndrome AT ingridsalinaszaldivar monoclonalgammopathyofrenalsignificancewithprogressiontomultiplemyelomainapatientwithasiamosyndrome |