Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans
Abstract Inhibiting prepotent responses in the face of external stop signals requires complex information processing, from perceptual to control processing. However, the cerebral circuits underlying these processes remain elusive. In this study, we used neuroimaging and brain stimulation to investig...
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54564-9 |
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| author | Takahiro Osada Koji Nakajima Tomohiko Shirokoshi Akitoshi Ogawa Satoshi Oka Koji Kamagata Shigeki Aoki Yasushi Oshima Sakae Tanaka Seiki Konishi |
| author_facet | Takahiro Osada Koji Nakajima Tomohiko Shirokoshi Akitoshi Ogawa Satoshi Oka Koji Kamagata Shigeki Aoki Yasushi Oshima Sakae Tanaka Seiki Konishi |
| author_sort | Takahiro Osada |
| collection | DOAJ |
| description | Abstract Inhibiting prepotent responses in the face of external stop signals requires complex information processing, from perceptual to control processing. However, the cerebral circuits underlying these processes remain elusive. In this study, we used neuroimaging and brain stimulation to investigate the interplay between human brain regions during response inhibition at the whole-brain level. Magnetic resonance imaging suggested a sequential four-step processing pathway: initiating from the primary visual cortex (V1), progressing to the dorsal anterior insula (daINS), then involving two essential regions in the inferior frontal cortex (IFC), namely the ventral posterior IFC (vpIFC) and anterior IFC (aIFC), and reaching the basal ganglia (BG)/primary motor cortex (M1). A combination of ultrasound stimulation and time-resolved magnetic stimulation elucidated the causal influence of daINS on vpIFC and the unidirectional dependence of aIFC on vpIFC. These results unveil asymmetric pathways in the insular-prefrontal cortex and outline the macroscopic cerebral circuits for response inhibition: V1→daINS→vpIFC/aIFC→BG/M1. |
| format | Article |
| id | doaj-art-cf59a1f4ff5b4123a2a5a020cd21c5d3 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Nature Communications |
| spelling | doaj-art-cf59a1f4ff5b4123a2a5a020cd21c5d32025-08-20T02:30:56ZengNature PortfolioNature Communications2041-17232024-12-0115111710.1038/s41467-024-54564-9Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humansTakahiro Osada0Koji Nakajima1Tomohiko Shirokoshi2Akitoshi Ogawa3Satoshi Oka4Koji Kamagata5Shigeki Aoki6Yasushi Oshima7Sakae Tanaka8Seiki Konishi9Department of Neurophysiology, Juntendo University School of MedicineDepartment of Neurophysiology, Juntendo University School of MedicineDepartment of Neurophysiology, Juntendo University School of MedicineDepartment of Neurophysiology, Juntendo University School of MedicineDepartment of Neurophysiology, Juntendo University School of MedicineDepartment of Radiology, Juntendo University School of MedicineDepartment of Radiology, Juntendo University School of MedicineDepartment of Orthopaedic Surgery, The University of Tokyo School of MedicineDepartment of Orthopaedic Surgery, The University of Tokyo School of MedicineDepartment of Neurophysiology, Juntendo University School of MedicineAbstract Inhibiting prepotent responses in the face of external stop signals requires complex information processing, from perceptual to control processing. However, the cerebral circuits underlying these processes remain elusive. In this study, we used neuroimaging and brain stimulation to investigate the interplay between human brain regions during response inhibition at the whole-brain level. Magnetic resonance imaging suggested a sequential four-step processing pathway: initiating from the primary visual cortex (V1), progressing to the dorsal anterior insula (daINS), then involving two essential regions in the inferior frontal cortex (IFC), namely the ventral posterior IFC (vpIFC) and anterior IFC (aIFC), and reaching the basal ganglia (BG)/primary motor cortex (M1). A combination of ultrasound stimulation and time-resolved magnetic stimulation elucidated the causal influence of daINS on vpIFC and the unidirectional dependence of aIFC on vpIFC. These results unveil asymmetric pathways in the insular-prefrontal cortex and outline the macroscopic cerebral circuits for response inhibition: V1→daINS→vpIFC/aIFC→BG/M1.https://doi.org/10.1038/s41467-024-54564-9 |
| spellingShingle | Takahiro Osada Koji Nakajima Tomohiko Shirokoshi Akitoshi Ogawa Satoshi Oka Koji Kamagata Shigeki Aoki Yasushi Oshima Sakae Tanaka Seiki Konishi Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans Nature Communications |
| title | Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans |
| title_full | Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans |
| title_fullStr | Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans |
| title_full_unstemmed | Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans |
| title_short | Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans |
| title_sort | multiple insular prefrontal pathways underlie perception to execution during response inhibition in humans |
| url | https://doi.org/10.1038/s41467-024-54564-9 |
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