Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy
Background: Antiphospholipid antibodies (aPL), a heterogeneous group of circulating antibodies including lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), & anti-beta-2-glycoprotein 1 antibodies (aβ2GP1) that have been associated with increased risks for thrombosis and adverse obstetr...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Marine Medical Society |
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| Online Access: | https://journals.lww.com/10.4103/jmms.jmms_85_24 |
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| author | Blessy Mathew Beenu Singh Gurpreet Kaur Metaanksha Ahuja Ahuja Ankur Gahlot P. S. Gaurav |
| author_facet | Blessy Mathew Beenu Singh Gurpreet Kaur Metaanksha Ahuja Ahuja Ankur Gahlot P. S. Gaurav |
| author_sort | Blessy Mathew |
| collection | DOAJ |
| description | Background:
Antiphospholipid antibodies (aPL), a heterogeneous group of circulating antibodies including lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), & anti-beta-2-glycoprotein 1 antibodies (aβ2GP1) that have been associated with increased risks for thrombosis and adverse obstetric outcomes.
Aims and Objectives:
The lupus anticoagulant tests have variable sensitivity of different clot-based assays i.e. aPTT-LA and dRVVT. The utility & comparison of each lupus anticoagulant assay will be analyzed in high-risk pregnancy clinics.
Materials and Methods:
This retrospective and prospective observational study was conducted over 200 high risk pregnancy cases from Nov 2017 to Jan 2018 at a tertiary care Armed Forces Institute. Equal number of high risk pregnancy cases as patients & normal antenatal patients matched for age as controls were included. 10 ml venous blood collected in tubes in a 9:1 ratio of blood to 3.2% trisodium citrate solution for lupus anticoagulant assay & 3 ml venous sample collected in serum vacutainer for anticardiolipin antibody assays. The STA-Staclot dRVV Screen and STA-Staclot dRVV Confirm kits were used for the detection of lupus anticoagulants in the plasma of patients. The Chi square test & results were analyzed using SPSS version 20.
Results:
A statistically significant positive association between history of IUGR with aCL IgG/IgM antibodies (p-value 0.008) and an insignificant association with the LAC assay was observed.
Conclusion:
Using both aPTT-LA & dRVVT tests as per ISTH recommendation resulted in more prevalence of LAC (24.6%). |
| format | Article |
| id | doaj-art-cf502e6a55be49f3adc041e60c3d7d11 |
| institution | DOAJ |
| issn | 0975-3605 2589-1235 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Marine Medical Society |
| spelling | doaj-art-cf502e6a55be49f3adc041e60c3d7d112025-08-20T02:57:47ZengWolters Kluwer Medknow PublicationsJournal of Marine Medical Society0975-36052589-12352025-05-0127218418810.4103/jmms.jmms_85_24Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk PregnancyBlessy MathewBeenu SinghGurpreet KaurMetaanksha AhujaAhuja AnkurGahlot P. S. GauravBackground: Antiphospholipid antibodies (aPL), a heterogeneous group of circulating antibodies including lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), & anti-beta-2-glycoprotein 1 antibodies (aβ2GP1) that have been associated with increased risks for thrombosis and adverse obstetric outcomes. Aims and Objectives: The lupus anticoagulant tests have variable sensitivity of different clot-based assays i.e. aPTT-LA and dRVVT. The utility & comparison of each lupus anticoagulant assay will be analyzed in high-risk pregnancy clinics. Materials and Methods: This retrospective and prospective observational study was conducted over 200 high risk pregnancy cases from Nov 2017 to Jan 2018 at a tertiary care Armed Forces Institute. Equal number of high risk pregnancy cases as patients & normal antenatal patients matched for age as controls were included. 10 ml venous blood collected in tubes in a 9:1 ratio of blood to 3.2% trisodium citrate solution for lupus anticoagulant assay & 3 ml venous sample collected in serum vacutainer for anticardiolipin antibody assays. The STA-Staclot dRVV Screen and STA-Staclot dRVV Confirm kits were used for the detection of lupus anticoagulants in the plasma of patients. The Chi square test & results were analyzed using SPSS version 20. Results: A statistically significant positive association between history of IUGR with aCL IgG/IgM antibodies (p-value 0.008) and an insignificant association with the LAC assay was observed. Conclusion: Using both aPTT-LA & dRVVT tests as per ISTH recommendation resulted in more prevalence of LAC (24.6%).https://journals.lww.com/10.4103/jmms.jmms_85_24antiphospholipid syndromeactivated partial prothrombin time-lupus anticoagulantdiluted russell’s viper venom testdeep vein thrombosishigh-risk pregnancy and recurrent abortionskaolin clotting timelupus anticoagulant |
| spellingShingle | Blessy Mathew Beenu Singh Gurpreet Kaur Metaanksha Ahuja Ahuja Ankur Gahlot P. S. Gaurav Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy Journal of Marine Medical Society antiphospholipid syndrome activated partial prothrombin time-lupus anticoagulant diluted russell’s viper venom test deep vein thrombosis high-risk pregnancy and recurrent abortions kaolin clotting time lupus anticoagulant |
| title | Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy |
| title_full | Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy |
| title_fullStr | Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy |
| title_full_unstemmed | Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy |
| title_short | Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy |
| title_sort | significance and correlation of lupus anticoagulant and anticardiolipin antibody assay in high risk pregnancy |
| topic | antiphospholipid syndrome activated partial prothrombin time-lupus anticoagulant diluted russell’s viper venom test deep vein thrombosis high-risk pregnancy and recurrent abortions kaolin clotting time lupus anticoagulant |
| url | https://journals.lww.com/10.4103/jmms.jmms_85_24 |
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