Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities
ABSTRACT This comprehensive investigation delves into the interconnectedness of different features of cardiometabolic syndrome, such as metabolic dysfunction‐associated steatotic liver disease (MASLD), atherosclerotic cardiovascular disease (ASCVD), and gut dysbiosis, highlighting the crucial role o...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Food Frontiers |
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| Online Access: | https://doi.org/10.1002/fft2.535 |
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| author | Laura Comi Claudia Giglione Fationa Tolaj Klinaku Federico Pialorsi Valentina Tollemeto Maria Zurlo Antonio Seneci Paolo Magni |
| author_facet | Laura Comi Claudia Giglione Fationa Tolaj Klinaku Federico Pialorsi Valentina Tollemeto Maria Zurlo Antonio Seneci Paolo Magni |
| author_sort | Laura Comi |
| collection | DOAJ |
| description | ABSTRACT This comprehensive investigation delves into the interconnectedness of different features of cardiometabolic syndrome, such as metabolic dysfunction‐associated steatotic liver disease (MASLD), atherosclerotic cardiovascular disease (ASCVD), and gut dysbiosis, highlighting the crucial role of nutraceuticals in their management and prevention. Given the significant overlap in the pathophysiology of these conditions, the treatment with nutraceuticals, especially those derived from agro‐food waste, offers a promising, sustainable, and innovative approach to healthcare. The 2030 Agenda for Sustainable Development and the One Health concept are key frameworks for selecting the most interesting supply chain for the production of nutraceuticals from agro‐food waste, ensuring environmental sustainability, and innovative agricultural practices. In this review, the therapeutic potential of kiwifruit and apples has been explored, detailing how their bioactive compounds, like polyphenols, fiber, pectin, kaempferol, phloretin, and phlorizin, may contribute to the management of MASLD, ASCVD, and gut dysbiosis. Various extraction methods for active ingredients, including chemical, water, and enzyme extractions, are analyzed for their respective benefits and drawbacks. By integrating scientific research, sustainable agricultural practices, and innovative extraction methods, we can develop effective strategies to combat these pervasive health issues. This holistic approach not only enhances individual health outcomes but also supports broader environmental and societal goals, promoting a healthier future for all. |
| format | Article |
| id | doaj-art-cf4a357887d14638aacb273dc98bbd2e |
| institution | Kabale University |
| issn | 2643-8429 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj-art-cf4a357887d14638aacb273dc98bbd2e2025-08-20T03:40:01ZengWileyFood Frontiers2643-84292025-03-016267069710.1002/fft2.535Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐MorbiditiesLaura Comi0Claudia Giglione1Fationa Tolaj Klinaku2Federico Pialorsi3Valentina Tollemeto4Maria Zurlo5Antonio Seneci6Paolo Magni7Department of Pharmacological and Biomolecular Sciences Università degli Studi di Milano Milan ItalyDepartment of Pharmacological and Biomolecular Sciences Università degli Studi di Milano Milan ItalyDepartment of Pharmacological and Biomolecular Sciences Università degli Studi di Milano Milan ItalyTruffini & Reggè Farmaceutici Milan ItalyTruffini & Reggè Farmaceutici Milan ItalyTruffini & Reggè Farmaceutici Milan ItalyTruffini & Reggè Farmaceutici Milan ItalyDepartment of Pharmacological and Biomolecular Sciences Università degli Studi di Milano Milan ItalyABSTRACT This comprehensive investigation delves into the interconnectedness of different features of cardiometabolic syndrome, such as metabolic dysfunction‐associated steatotic liver disease (MASLD), atherosclerotic cardiovascular disease (ASCVD), and gut dysbiosis, highlighting the crucial role of nutraceuticals in their management and prevention. Given the significant overlap in the pathophysiology of these conditions, the treatment with nutraceuticals, especially those derived from agro‐food waste, offers a promising, sustainable, and innovative approach to healthcare. The 2030 Agenda for Sustainable Development and the One Health concept are key frameworks for selecting the most interesting supply chain for the production of nutraceuticals from agro‐food waste, ensuring environmental sustainability, and innovative agricultural practices. In this review, the therapeutic potential of kiwifruit and apples has been explored, detailing how their bioactive compounds, like polyphenols, fiber, pectin, kaempferol, phloretin, and phlorizin, may contribute to the management of MASLD, ASCVD, and gut dysbiosis. Various extraction methods for active ingredients, including chemical, water, and enzyme extractions, are analyzed for their respective benefits and drawbacks. By integrating scientific research, sustainable agricultural practices, and innovative extraction methods, we can develop effective strategies to combat these pervasive health issues. This holistic approach not only enhances individual health outcomes but also supports broader environmental and societal goals, promoting a healthier future for all.https://doi.org/10.1002/fft2.535agro‐food wasteatherosclerotic cardiovascular diseasegut dysbiosismetabolic dysfunction‐associated steatotic liver diseasenutraceuticalssustainable extraction |
| spellingShingle | Laura Comi Claudia Giglione Fationa Tolaj Klinaku Federico Pialorsi Valentina Tollemeto Maria Zurlo Antonio Seneci Paolo Magni Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities Food Frontiers agro‐food waste atherosclerotic cardiovascular disease gut dysbiosis metabolic dysfunction‐associated steatotic liver disease nutraceuticals sustainable extraction |
| title | Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities |
| title_full | Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities |
| title_fullStr | Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities |
| title_full_unstemmed | Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities |
| title_short | Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities |
| title_sort | valorizing agro food waste for nutraceutical development sustainable approaches for managing metabolic dysfunction associated steatotic liver disease and related co morbidities |
| topic | agro‐food waste atherosclerotic cardiovascular disease gut dysbiosis metabolic dysfunction‐associated steatotic liver disease nutraceuticals sustainable extraction |
| url | https://doi.org/10.1002/fft2.535 |
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