Nitric oxide as a mediator of inflammation?—You had better believe it
Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, perox...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000639 |
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| _version_ | 1832561734191153152 |
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| author | Mark J. S. Miller Matthew B. Grisham |
| author_facet | Mark J. S. Miller Matthew B. Grisham |
| author_sort | Mark J. S. Miller |
| collection | DOAJ |
| description | Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation and effects on DNA (mutagenesis/apoptosis). We contend that there is ample evidence to consider nitric oxide as a molecular aggressor in inflammation, particularly chronic inflammation. Therapeutic benefit can be achieved by inhibition of inducible nitric oxide synthase and not the donation of additional nitric oxide. Furthermore, there is growing appreciation that nitric oxide and products derived thereof, are critical components linking the increased incidence of cancer in states of chronic inflammation. |
| format | Article |
| id | doaj-art-cf49610669614be5ba2afade9097031c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cf49610669614be5ba2afade9097031c2025-02-03T01:24:21ZengWileyMediators of Inflammation0962-93511466-18611995-01-014638739610.1155/S0962935195000639Nitric oxide as a mediator of inflammation?—You had better believe itMark J. S. Miller0Matthew B. Grisham1Department of Pediatrics, Louisiana State University Medical Center, New Orleans, LA, USADepartment of Physiology & Biophysics, Louisiana State University Medical Center, Shreveport LA, USANitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation and effects on DNA (mutagenesis/apoptosis). We contend that there is ample evidence to consider nitric oxide as a molecular aggressor in inflammation, particularly chronic inflammation. Therapeutic benefit can be achieved by inhibition of inducible nitric oxide synthase and not the donation of additional nitric oxide. Furthermore, there is growing appreciation that nitric oxide and products derived thereof, are critical components linking the increased incidence of cancer in states of chronic inflammation.http://dx.doi.org/10.1155/S0962935195000639 |
| spellingShingle | Mark J. S. Miller Matthew B. Grisham Nitric oxide as a mediator of inflammation?—You had better believe it Mediators of Inflammation |
| title | Nitric oxide as a mediator of inflammation?—You had better believe it |
| title_full | Nitric oxide as a mediator of inflammation?—You had better believe it |
| title_fullStr | Nitric oxide as a mediator of inflammation?—You had better believe it |
| title_full_unstemmed | Nitric oxide as a mediator of inflammation?—You had better believe it |
| title_short | Nitric oxide as a mediator of inflammation?—You had better believe it |
| title_sort | nitric oxide as a mediator of inflammation you had better believe it |
| url | http://dx.doi.org/10.1155/S0962935195000639 |
| work_keys_str_mv | AT markjsmiller nitricoxideasamediatorofinflammationyouhadbetterbelieveit AT matthewbgrisham nitricoxideasamediatorofinflammationyouhadbetterbelieveit |