Autophagy: A Primer for the Gastroenterologist/Hepatologist
Autophagy is a conserved cellular pathway that maintains intracellular homeostasis by degrading proteins and cytosolic contents of eukaryotic cells. Autophagy clears misfolded and long-lived proteins, damaged organelles and invading microorganisms from cells, and provides nutrients and energy in res...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2011/581264 |
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| _version_ | 1849472268762087424 |
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| author | Christiane Sokollik Michelle Ang Nicola L Jones |
| author_facet | Christiane Sokollik Michelle Ang Nicola L Jones |
| author_sort | Christiane Sokollik |
| collection | DOAJ |
| description | Autophagy is a conserved cellular pathway that maintains intracellular homeostasis by degrading proteins and cytosolic contents of eukaryotic cells. Autophagy clears misfolded and long-lived proteins, damaged organelles and invading microorganisms from cells, and provides nutrients and energy in response to exposure to cell stressors such as starvation. Defective autophagy has recently been linked to a diverse range of disease processes of relevance to gastroenterologists and hepatologists including Crohn’s disease, pancreatitis, hepatitis and cancer. The present article provides an overview of the autophagy pathway and discusses gastrointestinal disease processes in which alterations in autophagy have been implicated. The clinical significance of autophagy as a potential therapeutic option is also discussed. |
| format | Article |
| id | doaj-art-cf47c9fd3d6d46e4b1984cd6ce5ad435 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-cf47c9fd3d6d46e4b1984cd6ce5ad4352025-08-20T03:24:34ZengWileyCanadian Journal of Gastroenterology0835-79002011-01-01251266767410.1155/2011/581264Autophagy: A Primer for the Gastroenterologist/HepatologistChristiane Sokollik0Michelle Ang1Nicola L Jones2Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children; Departments of Paediatrics and Physiology, University of Toronto, Toronto, Ontario, CanadaDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children; Departments of Paediatrics and Physiology, University of Toronto, Toronto, Ontario, CanadaDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children; Departments of Paediatrics and Physiology, University of Toronto, Toronto, Ontario, CanadaAutophagy is a conserved cellular pathway that maintains intracellular homeostasis by degrading proteins and cytosolic contents of eukaryotic cells. Autophagy clears misfolded and long-lived proteins, damaged organelles and invading microorganisms from cells, and provides nutrients and energy in response to exposure to cell stressors such as starvation. Defective autophagy has recently been linked to a diverse range of disease processes of relevance to gastroenterologists and hepatologists including Crohn’s disease, pancreatitis, hepatitis and cancer. The present article provides an overview of the autophagy pathway and discusses gastrointestinal disease processes in which alterations in autophagy have been implicated. The clinical significance of autophagy as a potential therapeutic option is also discussed.http://dx.doi.org/10.1155/2011/581264 |
| spellingShingle | Christiane Sokollik Michelle Ang Nicola L Jones Autophagy: A Primer for the Gastroenterologist/Hepatologist Canadian Journal of Gastroenterology |
| title | Autophagy: A Primer for the Gastroenterologist/Hepatologist |
| title_full | Autophagy: A Primer for the Gastroenterologist/Hepatologist |
| title_fullStr | Autophagy: A Primer for the Gastroenterologist/Hepatologist |
| title_full_unstemmed | Autophagy: A Primer for the Gastroenterologist/Hepatologist |
| title_short | Autophagy: A Primer for the Gastroenterologist/Hepatologist |
| title_sort | autophagy a primer for the gastroenterologist hepatologist |
| url | http://dx.doi.org/10.1155/2011/581264 |
| work_keys_str_mv | AT christianesokollik autophagyaprimerforthegastroenterologisthepatologist AT michelleang autophagyaprimerforthegastroenterologisthepatologist AT nicolaljones autophagyaprimerforthegastroenterologisthepatologist |