Lung cancer screening: advancing early detection and improving outcomes
Abstract Lung cancer remains the leading cause of cancer death worldwide, mainly due to late diagnoses. While low-dose computed tomography (LDCT) screening reduces mortality in high-risk groups, false positives and low nodule specificity remain major challenges. High nodule prevalence even in nonsmo...
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| Format: | Article |
| Language: | English |
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Springer
2025-08-01
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| Series: | Holistic Integrative Oncology |
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| Online Access: | https://doi.org/10.1007/s44178-025-00188-y |
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| _version_ | 1849388729935855616 |
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| author | Geertruida H. de Bock |
| author_facet | Geertruida H. de Bock |
| author_sort | Geertruida H. de Bock |
| collection | DOAJ |
| description | Abstract Lung cancer remains the leading cause of cancer death worldwide, mainly due to late diagnoses. While low-dose computed tomography (LDCT) screening reduces mortality in high-risk groups, false positives and low nodule specificity remain major challenges. High nodule prevalence even in nonsmokers further highlights the need for better risk stratification. Improved screening may be achieved through refined nodule assessment, sex-specific models, and emerging biomarkers like blood-based assays. Integrating these tools can enhance accuracy and reduce harms. Continued efforts to promote smoking cessation and improve air quality are also crucial. |
| format | Article |
| id | doaj-art-cf4097a68ea14377a9bc918b3d5f1a42 |
| institution | Kabale University |
| issn | 2731-4529 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Holistic Integrative Oncology |
| spelling | doaj-art-cf4097a68ea14377a9bc918b3d5f1a422025-08-20T03:42:10ZengSpringerHolistic Integrative Oncology2731-45292025-08-01411310.1007/s44178-025-00188-yLung cancer screening: advancing early detection and improving outcomesGeertruida H. de Bock0Department of Epidemiology, University of Groningen, University Medical Center GroningenAbstract Lung cancer remains the leading cause of cancer death worldwide, mainly due to late diagnoses. While low-dose computed tomography (LDCT) screening reduces mortality in high-risk groups, false positives and low nodule specificity remain major challenges. High nodule prevalence even in nonsmokers further highlights the need for better risk stratification. Improved screening may be achieved through refined nodule assessment, sex-specific models, and emerging biomarkers like blood-based assays. Integrating these tools can enhance accuracy and reduce harms. Continued efforts to promote smoking cessation and improve air quality are also crucial.https://doi.org/10.1007/s44178-025-00188-yLung cancerPopulation-based screeningRisk stratificationSmoking cessation |
| spellingShingle | Geertruida H. de Bock Lung cancer screening: advancing early detection and improving outcomes Holistic Integrative Oncology Lung cancer Population-based screening Risk stratification Smoking cessation |
| title | Lung cancer screening: advancing early detection and improving outcomes |
| title_full | Lung cancer screening: advancing early detection and improving outcomes |
| title_fullStr | Lung cancer screening: advancing early detection and improving outcomes |
| title_full_unstemmed | Lung cancer screening: advancing early detection and improving outcomes |
| title_short | Lung cancer screening: advancing early detection and improving outcomes |
| title_sort | lung cancer screening advancing early detection and improving outcomes |
| topic | Lung cancer Population-based screening Risk stratification Smoking cessation |
| url | https://doi.org/10.1007/s44178-025-00188-y |
| work_keys_str_mv | AT geertruidahdebock lungcancerscreeningadvancingearlydetectionandimprovingoutcomes |