The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential
The global prevalence of type 2 diabetes mellitus (T2DM) necessitates the exploration of novel therapeutic approaches to mitigate its complex molecular pathogenesis. This review investigates the potential role of genistein, a prominent isoflavone derived from soybeans, in the management of T2DM. Rec...
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MDPI AG
2025-02-01
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| author | Mateusz Kciuk Weronika Kruczkowska Katarzyna Wanke Julia Gałęziewska Damian Kołat Somdutt Mujwar Renata Kontek |
| author_facet | Mateusz Kciuk Weronika Kruczkowska Katarzyna Wanke Julia Gałęziewska Damian Kołat Somdutt Mujwar Renata Kontek |
| author_sort | Mateusz Kciuk |
| collection | DOAJ |
| description | The global prevalence of type 2 diabetes mellitus (T2DM) necessitates the exploration of novel therapeutic approaches to mitigate its complex molecular pathogenesis. This review investigates the potential role of genistein, a prominent isoflavone derived from soybeans, in the management of T2DM. Recognized for its selective estrogen receptor modulator (SERM) activity, genistein exerts a multifaceted influence on key intracellular signaling pathways, which are crucial in regulating cell proliferation, apoptosis, and insulin signaling. Genistein’s anti-inflammatory, anti-oxidant, and metabolic regulatory properties position it as a promising candidate for T2DM intervention. This review synthesizes current research spanning preclinical studies and clinical trials, emphasizing genistein’s impact on insulin sensitivity, glucose metabolism, and inflammatory markers. Additionally, this review addresses genistein’s bioavailability, safety, and potential influence on gut microbiota composition. By consolidating these findings, this review aims to provide a comprehensive understanding of genistein’s therapeutic potential in T2DM management, offering valuable insights for future research and clinical practice. |
| format | Article |
| id | doaj-art-cf3dc13bc8e54c5bb5bab4bdb383cba4 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-cf3dc13bc8e54c5bb5bab4bdb383cba42025-08-20T02:06:12ZengMDPI AGMolecules1420-30492025-02-01305106810.3390/molecules30051068The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic PotentialMateusz Kciuk0Weronika Kruczkowska1Katarzyna Wanke2Julia Gałęziewska3Damian Kołat4Somdutt Mujwar5Renata Kontek6Department of Molecular Biotechnology and Genetics, Univeristy of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Żeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Molecular Biotechnology and Genetics, Univeristy of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Żeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Żeligowskiego 7/9, 90-752 Lodz, PolandChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, IndiaDepartment of Molecular Biotechnology and Genetics, Univeristy of Lodz, Banacha 12/16, 90-237 Lodz, PolandThe global prevalence of type 2 diabetes mellitus (T2DM) necessitates the exploration of novel therapeutic approaches to mitigate its complex molecular pathogenesis. This review investigates the potential role of genistein, a prominent isoflavone derived from soybeans, in the management of T2DM. Recognized for its selective estrogen receptor modulator (SERM) activity, genistein exerts a multifaceted influence on key intracellular signaling pathways, which are crucial in regulating cell proliferation, apoptosis, and insulin signaling. Genistein’s anti-inflammatory, anti-oxidant, and metabolic regulatory properties position it as a promising candidate for T2DM intervention. This review synthesizes current research spanning preclinical studies and clinical trials, emphasizing genistein’s impact on insulin sensitivity, glucose metabolism, and inflammatory markers. Additionally, this review addresses genistein’s bioavailability, safety, and potential influence on gut microbiota composition. By consolidating these findings, this review aims to provide a comprehensive understanding of genistein’s therapeutic potential in T2DM management, offering valuable insights for future research and clinical practice.https://www.mdpi.com/1420-3049/30/5/1068anti-oxidantbioavailabilitygenisteinmetabolic diseasenatural producttype 2 diabetes mellitus |
| spellingShingle | Mateusz Kciuk Weronika Kruczkowska Katarzyna Wanke Julia Gałęziewska Damian Kołat Somdutt Mujwar Renata Kontek The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential Molecules anti-oxidant bioavailability genistein metabolic disease natural product type 2 diabetes mellitus |
| title | The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential |
| title_full | The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential |
| title_fullStr | The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential |
| title_full_unstemmed | The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential |
| title_short | The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential |
| title_sort | role of genistein in type 2 diabetes and beyond mechanisms and therapeutic potential |
| topic | anti-oxidant bioavailability genistein metabolic disease natural product type 2 diabetes mellitus |
| url | https://www.mdpi.com/1420-3049/30/5/1068 |
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