TLR4 Asp299Gly SNP (rs4986790) Protects from Periodontal Inflammatory Destruction by Altering TLR4 Susceptibility to LPS Stimulation

TLR4 Asp299Gly SNP (rs4986790) Protects from Periodontal Inflammatory Destruction by Altering TLR4 Susceptibility to LPS Stimulation

Periodontitis is a multifactorial disease linked to host immune response and genetic predisposition. The TLR4 Asp299Gly single-nucleotide polymorphism (SNP, rs4986790) has been associated with altered responses to bacterial lipopolysaccharide (LPS) and may influence susceptibility to inflammatory di...

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Bibliographic Details
Main Authors: Franco Cavalla, Claudia C. Biguetti, Ariadne Letra, Renato M. Silva, Alexandre R. Vieira, Franz J. Strauss, Gustavo P. Garlet
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biology
Subjects:
periodontitis
TLR4
SNP
rs4986790
inflammation
LPS
Online Access:https://www.mdpi.com/2079-7737/14/7/894
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