Patient-specific HLA-I subtypes predict response to immune checkpoint blockade

Patient-specific HLA-I subtypes predict response to immune checkpoint blockade

Specific shared HLA-I alleles were linked to the response to immune checkpoint blockade (ICB). We aimed to identify the HLA-A subtypes associated with maximum benefit from ICB. We compiled a clinical dataset of patients who underwent a CLIA-approved germline HLA status testing as part of various adv...

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Bibliographic Details
Main Authors: Kyrillus S. Shohdy, Jack Atherton, Jessica Longland, Jennifer Alison, Manon Pillai, Fiona Thistlethwaite
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Advanced cancer
HLA subtype
immune checkpoint
predictive biomarkers
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2462386
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