Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut Microbiota
Several studies have demonstrated that exercise preconditioning is an effective means of alleviating poststroke cognitive impairment (PSCI). Mechanisms of regulating cognitive function have not been fully elucidated. Herein, the present study is aimed at exploring the effect of the microbiota-gut-in...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/2124230 |
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| author | Heng Lv Shasha Wang Meihui Tian Liya Wang Jie Gao Qitao Zhao Zhaoyu Li Xianjie Jia Ying Yu |
| author_facet | Heng Lv Shasha Wang Meihui Tian Liya Wang Jie Gao Qitao Zhao Zhaoyu Li Xianjie Jia Ying Yu |
| author_sort | Heng Lv |
| collection | DOAJ |
| description | Several studies have demonstrated that exercise preconditioning is an effective means of alleviating poststroke cognitive impairment (PSCI). Mechanisms of regulating cognitive function have not been fully elucidated. Herein, the present study is aimed at exploring the effect of the microbiota-gut-inflammasome-brain axis in the process of exercise preconditioning moderating cognitive impairment after ischemic stroke. We observed that exercise preconditioning decreased infarct size, reduced the degree of neuronal damage, and alleviated cognitive impairment in mice with ischemic stroke. In addition, exercise preconditioning also reduced the expression of inflammatory cytokines, as well as NLRP3, Caspase-1, IL-18, and IL-1β protein expressions. Ischemic stroke could downregulate the abundance of Roseburia while increasing the abundance of the Helicobacter at the level of genus. As a comparison, exercise preconditioning increased the abundance of the Lactobacillus, which was beneficial for mice at the genus level. In conclusion, exercise preconditioning can improve cognitive dysfunction after ischemic stroke through alleviating inflammation and regulating the composition and diversity of the gut microbiota, which might provide a new strategy for the prevention of PSCI. |
| format | Article |
| id | doaj-art-cf35bcf64adb473782636f6bbb70de8b |
| institution | OA Journals |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cf35bcf64adb473782636f6bbb70de8b2025-08-20T02:20:08ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/2124230Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut MicrobiotaHeng Lv0Shasha Wang1Meihui Tian2Liya Wang3Jie Gao4Qitao Zhao5Zhaoyu Li6Xianjie Jia7Ying Yu8Department of Epidemiology and StatisticsKey Laboratory of Cardiovascular and Cerebrovascular DiseasesDepartment of Epidemiology and StatisticsKey Laboratory of Cardiovascular and Cerebrovascular DiseasesKey Laboratory of Cardiovascular and Cerebrovascular DiseasesKey Laboratory of Cardiovascular and Cerebrovascular DiseasesKey Laboratory of Cardiovascular and Cerebrovascular DiseasesDepartment of Epidemiology and StatisticsKey Laboratory of Cardiovascular and Cerebrovascular DiseasesSeveral studies have demonstrated that exercise preconditioning is an effective means of alleviating poststroke cognitive impairment (PSCI). Mechanisms of regulating cognitive function have not been fully elucidated. Herein, the present study is aimed at exploring the effect of the microbiota-gut-inflammasome-brain axis in the process of exercise preconditioning moderating cognitive impairment after ischemic stroke. We observed that exercise preconditioning decreased infarct size, reduced the degree of neuronal damage, and alleviated cognitive impairment in mice with ischemic stroke. In addition, exercise preconditioning also reduced the expression of inflammatory cytokines, as well as NLRP3, Caspase-1, IL-18, and IL-1β protein expressions. Ischemic stroke could downregulate the abundance of Roseburia while increasing the abundance of the Helicobacter at the level of genus. As a comparison, exercise preconditioning increased the abundance of the Lactobacillus, which was beneficial for mice at the genus level. In conclusion, exercise preconditioning can improve cognitive dysfunction after ischemic stroke through alleviating inflammation and regulating the composition and diversity of the gut microbiota, which might provide a new strategy for the prevention of PSCI.http://dx.doi.org/10.1155/2022/2124230 |
| spellingShingle | Heng Lv Shasha Wang Meihui Tian Liya Wang Jie Gao Qitao Zhao Zhaoyu Li Xianjie Jia Ying Yu Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut Microbiota Mediators of Inflammation |
| title | Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut Microbiota |
| title_full | Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut Microbiota |
| title_fullStr | Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut Microbiota |
| title_full_unstemmed | Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut Microbiota |
| title_short | Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut Microbiota |
| title_sort | exercise preconditioning ameliorates cognitive impairment in mice with ischemic stroke by alleviating inflammation and modulating gut microbiota |
| url | http://dx.doi.org/10.1155/2022/2124230 |
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