Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis
Tuberculosis and its pathogen, Mycobacterium tuberculosis complex, are a major health challenge. The causative agent of tuberculosis is M. tuberculosis complex and is transmitted through airborne droplets. Tumor necrosis factor-alpha (TNF-α) is one of the cytokines that mediate a major role in the c...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | International Journal of Mycobacteriology |
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| Online Access: | https://journals.lww.com/10.4103/ijmy.ijmy_71_25 |
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| author | Jalaledin Ghanavi Poopak Farnia |
| author_facet | Jalaledin Ghanavi Poopak Farnia |
| author_sort | Jalaledin Ghanavi |
| collection | DOAJ |
| description | Tuberculosis and its pathogen, Mycobacterium tuberculosis complex, are a major health challenge. The causative agent of tuberculosis is M. tuberculosis complex and is transmitted through airborne droplets. Tumor necrosis factor-alpha (TNF-α) is one of the cytokines that mediate a major role in the cellular immune response to tuberculosis and is essential for pathogen clearance, control of mycobacterial growth, and facilitation of apoptosis of infected cells. Susceptibility to tuberculosis and disease progression are influenced by environmental factors and the host’s genetic predisposition. TNF polymorphisms affect disease susceptibility and patient response to drugs and treatment. Various studies have been conducted to associate TNF polymorphisms with susceptibility to tuberculosis. This activity aims to review the role of TNF-α cytokine and the impact of its polymorphisms on the occurrence of tuberculosis and compiles recent mechanistic and epidemiological findings. |
| format | Article |
| id | doaj-art-cf34291e96904c0d8fc3579e3c0bbcdb |
| institution | Kabale University |
| issn | 2212-5531 2212-554X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj-art-cf34291e96904c0d8fc3579e3c0bbcdb2025-08-20T03:29:39ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2025-04-01142899510.4103/ijmy.ijmy_71_25Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of TuberculosisJalaledin GhanaviPoopak FarniaTuberculosis and its pathogen, Mycobacterium tuberculosis complex, are a major health challenge. The causative agent of tuberculosis is M. tuberculosis complex and is transmitted through airborne droplets. Tumor necrosis factor-alpha (TNF-α) is one of the cytokines that mediate a major role in the cellular immune response to tuberculosis and is essential for pathogen clearance, control of mycobacterial growth, and facilitation of apoptosis of infected cells. Susceptibility to tuberculosis and disease progression are influenced by environmental factors and the host’s genetic predisposition. TNF polymorphisms affect disease susceptibility and patient response to drugs and treatment. Various studies have been conducted to associate TNF polymorphisms with susceptibility to tuberculosis. This activity aims to review the role of TNF-α cytokine and the impact of its polymorphisms on the occurrence of tuberculosis and compiles recent mechanistic and epidemiological findings.https://journals.lww.com/10.4103/ijmy.ijmy_71_25immune responsemycobacterium tuberculosispolymorphismtumor necrosis factor-alpha |
| spellingShingle | Jalaledin Ghanavi Poopak Farnia Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis International Journal of Mycobacteriology immune response mycobacterium tuberculosis polymorphism tumor necrosis factor-alpha |
| title | Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis |
| title_full | Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis |
| title_fullStr | Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis |
| title_full_unstemmed | Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis |
| title_short | Studying the Effect of Tumor Necrosis Factor-Alpha and Tumor Necrosis Factor Gene Polymorphisms on the Incidence of Tuberculosis |
| title_sort | studying the effect of tumor necrosis factor alpha and tumor necrosis factor gene polymorphisms on the incidence of tuberculosis |
| topic | immune response mycobacterium tuberculosis polymorphism tumor necrosis factor-alpha |
| url | https://journals.lww.com/10.4103/ijmy.ijmy_71_25 |
| work_keys_str_mv | AT jalaledinghanavi studyingtheeffectoftumornecrosisfactoralphaandtumornecrosisfactorgenepolymorphismsontheincidenceoftuberculosis AT poopakfarnia studyingtheeffectoftumornecrosisfactoralphaandtumornecrosisfactorgenepolymorphismsontheincidenceoftuberculosis |