Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities
Abstract Remarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and a cell lysis phase, the latter of which is irreversible. Besides immune cells, pyroptosis has also been o...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Biomarker Research |
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| Online Access: | https://doi.org/10.1186/s40364-025-00771-5 |
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| author | Rui Miao Xueying Wang Jingyv Zhang Qinyv Kang Qing Liu Xianglin Luo Junwei Hou Baorong Gao |
| author_facet | Rui Miao Xueying Wang Jingyv Zhang Qinyv Kang Qing Liu Xianglin Luo Junwei Hou Baorong Gao |
| author_sort | Rui Miao |
| collection | DOAJ |
| description | Abstract Remarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and a cell lysis phase, the latter of which is irreversible. Besides immune cells, pyroptosis has also been observed in cancer cells, which exhibit distinct mechanisms compared to canonical immune cell pyroptosis. Although chronic cancer cell pyroptosis fuels tumor growth, intense pyroptotic cell death in tumor cells enhances anticancer immunity by promoting killer lymphocytes infiltration. Triggering pyroptosis in cancer cells is emerging as a promising strategy for cancer treatment. In this review, we introduce the process of cancer cell pyroptosis and its role in antitumor immunity, discuss the translation of these insights into therapies, and highlight current challenges and opportunities in the investigation of cancer cell pyroptosis. |
| format | Article |
| id | doaj-art-cf326dee50ce4b9bb00d0d3a0d73b977 |
| institution | DOAJ |
| issn | 2050-7771 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-cf326dee50ce4b9bb00d0d3a0d73b9772025-08-20T03:09:19ZengBMCBiomarker Research2050-77712025-04-0113111210.1186/s40364-025-00771-5Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunitiesRui Miao0Xueying Wang1Jingyv Zhang2Qinyv Kang3Qing Liu4Xianglin Luo5Junwei Hou6Baorong Gao7Department of Otolaryngology Head and Neck Surgery, Central South UniversityDepartment of Otolaryngology Head and Neck Surgery, Central South UniversityDepartment of Otolaryngology Head and Neck Surgery, Central South UniversityDepartment of Otolaryngology Head and Neck Surgery, Central South UniversityDepartment of Otolaryngology Head and Neck Surgery, Central South UniversityDepartment of Otolaryngology Head and Neck Surgery, Central South UniversityDepartment of Otolaryngology Head and Neck Surgery, Central South UniversityKey Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, Sichuan UniversityAbstract Remarkable advances have been achieved following discoveries that gasdermins are the executioners of pyroptosis. The pyroptotic process consists a subcellular permeabilization phase and a cell lysis phase, the latter of which is irreversible. Besides immune cells, pyroptosis has also been observed in cancer cells, which exhibit distinct mechanisms compared to canonical immune cell pyroptosis. Although chronic cancer cell pyroptosis fuels tumor growth, intense pyroptotic cell death in tumor cells enhances anticancer immunity by promoting killer lymphocytes infiltration. Triggering pyroptosis in cancer cells is emerging as a promising strategy for cancer treatment. In this review, we introduce the process of cancer cell pyroptosis and its role in antitumor immunity, discuss the translation of these insights into therapies, and highlight current challenges and opportunities in the investigation of cancer cell pyroptosis.https://doi.org/10.1186/s40364-025-00771-5PyroptosisGasderminsAnti-tumor immunityCell deathTumor cells |
| spellingShingle | Rui Miao Xueying Wang Jingyv Zhang Qinyv Kang Qing Liu Xianglin Luo Junwei Hou Baorong Gao Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities Biomarker Research Pyroptosis Gasdermins Anti-tumor immunity Cell death Tumor cells |
| title | Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities |
| title_full | Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities |
| title_fullStr | Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities |
| title_full_unstemmed | Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities |
| title_short | Manipulation of cancer cell pyroptosis for therapeutic approaches: challenges and opportunities |
| title_sort | manipulation of cancer cell pyroptosis for therapeutic approaches challenges and opportunities |
| topic | Pyroptosis Gasdermins Anti-tumor immunity Cell death Tumor cells |
| url | https://doi.org/10.1186/s40364-025-00771-5 |
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