CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism

CCN5 negatively regulates TGF-β-induced endometriosis associated fibrosis through Wnt/β-catenin signaling via Smad3-dependent mechanism

Abstract Background Fibrogenesis is a common pathological feature of endometriotic lesions and contributes to the development of endometriosis-associated chronic pelvic pain and infertility. TGF-β is a critical factor in the induction of fibrogenesis; however, the underlying regulatory mechanisms of...

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Bibliographic Details
Main Authors: Mian Liu, Yi Gong, Hong Cai, Rui Hua, Hong Li, Zhe Wang, Yao Zhou, Yanlin Ma, Song Quan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Endometriosis
CCN5
TGF-β
Fibrosis
Wnt/β-catenin
Smad
Online Access:https://doi.org/10.1186/s12967-025-06804-9
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