Association between systemic immune inflammation index and cataract incidence from 2005 to 2008
Abstract The objective of this study is to investigate the association between the Systemic Immune-Inflammation Index (SII) and cataracts. This cross-sectional study analyzed data from the 2005–2008 NHANES to examine the relationship between the SII and cataract prevalence. Covariates included age,...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84204-7 |
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| author | Xiang Li Guo-lei Du Shi-Nan Wu Yi-qing Sun Si-Qi Zhang Zhi-Jie Zhang Jia-feng Tang |
| author_facet | Xiang Li Guo-lei Du Shi-Nan Wu Yi-qing Sun Si-Qi Zhang Zhi-Jie Zhang Jia-feng Tang |
| author_sort | Xiang Li |
| collection | DOAJ |
| description | Abstract The objective of this study is to investigate the association between the Systemic Immune-Inflammation Index (SII) and cataracts. This cross-sectional study analyzed data from the 2005–2008 NHANES to examine the relationship between the SII and cataract prevalence. Covariates included age, race/ethnicity, gender, education level, marital status, Body Mass Index (BMI), smoking, alcohol consumption, hypertension, hyperlipidemia, and diabetes. Multivariable logistic regression was used to assess the association, while spline curve fitting explored potential non-linear relationships. Threshold analysis identified critical inflection points. To address age-related bias, Propensity Score Matching (PSM) was performed, aligning cataract patients with comparable non-cataract individuals for further evaluation. Our study included 3,623 participants, of whom 730 (20.15%) were diagnosed with cataracts. After adjusting for all covariates, multivariable logistic regression analysis demonstrated that elevated levels of the SII were significantly associated with increased odds of cataracts (Model1: OR = 1.56; 95%CI [1.33–1.85]; Model2: OR = 1.55; 95%CI [1.32–1.84]; Model3: OR = 1.57; 95%CI [1.33–1.86]). In the spline curve fitting model, the relationship between ln-SII and cataract prevalence was non-linear (P < 0.001), with a critical inflection point identified at an SII of 428.38. SII levels remained significantly associated with cataract prevalence following PSM adjustments (Model 1: OR = 1.48; 95% CI [1.21–1.80]; Model 2: OR = 1.48; 95% CI [1.21–1.80]; Model 3: OR = 1.46; 95% CI [1.20–1.78]). Elevated SII levels are associated with a higher prevalence of cataracts, underscoring the pivotal role of systemic inflammation in cataract development. These findings indicate that SII could serve as a valuable biomarker for assessing cataract risk, further emphasizing the significance of managing systemic inflammation as a potential strategy for cataract prevention. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-cf2e5631eadc4cbe9e526edfa558ee7a2025-08-20T02:46:07ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-024-84204-7Association between systemic immune inflammation index and cataract incidence from 2005 to 2008Xiang Li0Guo-lei Du1Shi-Nan Wu2Yi-qing Sun3Si-Qi Zhang4Zhi-Jie Zhang5Jia-feng Tang6Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen UniversityWeihai Institute for Bionics-Jilin UniversityEye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen UniversityThe First Affiliated Hospital of Xi’an Jiao Tong UniversityWeihai Institute for Bionics-Jilin UniversityKunming Medical UniversityChongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical CollegeAbstract The objective of this study is to investigate the association between the Systemic Immune-Inflammation Index (SII) and cataracts. This cross-sectional study analyzed data from the 2005–2008 NHANES to examine the relationship between the SII and cataract prevalence. Covariates included age, race/ethnicity, gender, education level, marital status, Body Mass Index (BMI), smoking, alcohol consumption, hypertension, hyperlipidemia, and diabetes. Multivariable logistic regression was used to assess the association, while spline curve fitting explored potential non-linear relationships. Threshold analysis identified critical inflection points. To address age-related bias, Propensity Score Matching (PSM) was performed, aligning cataract patients with comparable non-cataract individuals for further evaluation. Our study included 3,623 participants, of whom 730 (20.15%) were diagnosed with cataracts. After adjusting for all covariates, multivariable logistic regression analysis demonstrated that elevated levels of the SII were significantly associated with increased odds of cataracts (Model1: OR = 1.56; 95%CI [1.33–1.85]; Model2: OR = 1.55; 95%CI [1.32–1.84]; Model3: OR = 1.57; 95%CI [1.33–1.86]). In the spline curve fitting model, the relationship between ln-SII and cataract prevalence was non-linear (P < 0.001), with a critical inflection point identified at an SII of 428.38. SII levels remained significantly associated with cataract prevalence following PSM adjustments (Model 1: OR = 1.48; 95% CI [1.21–1.80]; Model 2: OR = 1.48; 95% CI [1.21–1.80]; Model 3: OR = 1.46; 95% CI [1.20–1.78]). Elevated SII levels are associated with a higher prevalence of cataracts, underscoring the pivotal role of systemic inflammation in cataract development. These findings indicate that SII could serve as a valuable biomarker for assessing cataract risk, further emphasizing the significance of managing systemic inflammation as a potential strategy for cataract prevention.https://doi.org/10.1038/s41598-024-84204-7Systemic immune-inflammation indexCataractsNHANESSystemic inflammationRisk assessment |
| spellingShingle | Xiang Li Guo-lei Du Shi-Nan Wu Yi-qing Sun Si-Qi Zhang Zhi-Jie Zhang Jia-feng Tang Association between systemic immune inflammation index and cataract incidence from 2005 to 2008 Scientific Reports Systemic immune-inflammation index Cataracts NHANES Systemic inflammation Risk assessment |
| title | Association between systemic immune inflammation index and cataract incidence from 2005 to 2008 |
| title_full | Association between systemic immune inflammation index and cataract incidence from 2005 to 2008 |
| title_fullStr | Association between systemic immune inflammation index and cataract incidence from 2005 to 2008 |
| title_full_unstemmed | Association between systemic immune inflammation index and cataract incidence from 2005 to 2008 |
| title_short | Association between systemic immune inflammation index and cataract incidence from 2005 to 2008 |
| title_sort | association between systemic immune inflammation index and cataract incidence from 2005 to 2008 |
| topic | Systemic immune-inflammation index Cataracts NHANES Systemic inflammation Risk assessment |
| url | https://doi.org/10.1038/s41598-024-84204-7 |
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