ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY
Objective: Lupus nephritis (LN) is a detrimental consequence of systemic lupus erythematosus (SLE). The anti-C1q antibody was shown to be related to LN, or global disease activity, in various studies. Our purpose was to determine its prevalence and association with LN or disease activity in Turkish...
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Istanbul University Press
2024-10-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9A65D4D7883F480EA063A1F527EC022A |
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| author | Senem Tekeoğlu Duygu Temiz Karadağ Özlem Özdemir Işık Aylin Göçoğlu Fatma Ceyla Eraldemir Ayten Yazıcı Ayşe Çefle |
| author_facet | Senem Tekeoğlu Duygu Temiz Karadağ Özlem Özdemir Işık Aylin Göçoğlu Fatma Ceyla Eraldemir Ayten Yazıcı Ayşe Çefle |
| author_sort | Senem Tekeoğlu |
| collection | DOAJ |
| description | Objective: Lupus nephritis (LN) is a detrimental consequence of systemic lupus erythematosus (SLE). The anti-C1q antibody was shown to be related to LN, or global disease activity, in various studies. Our purpose was to determine its prevalence and association with LN or disease activity in Turkish patients with SLE. Material and Method: We conducted a cross-sectional single-centre study to investigate the clinical and laboratory findings, disease activity, and anti-C1q levels in 150 patients with SLE. The anti-C1q antibody was analyzed using an enzyme-linked immunosorbent assay and compared with 150 healthy-control patients. Result: Lupus nephritis was present in 72 patients. The frequency of anti-C1q positivity was 17% (26/150) in patients with SLE and 3% (5/150) in control group (p<0.001). Patients with anti-C1q also had anti-Sm, direct Coombs’ test, and thrombocytopenia more commonly (p=0.001, p=0.007, p=0.009 respectively). Anti-C1q was positively correlated with proteinuria, haematuria, systemic lupus erythematosus disease activity index (SLEDAI) (p<0.001), anti-dsDNA (p=0.03), and negatively correlated with C3 (p<0.001) and C4 (p=0.015). Patients with active LN had higher anti-C1q (p=0.01) and anti-dsDNA (p<0.001) titres than inactive LN patients, although in multivariate logistic regression analysis, anti-C1q was not significant for LN history. It was significant for SLEDAI severity (p=0.036). Conclusion: Our study demonstrated a significant association of anti-C1q with SLE, proteinuria, haematuria, thrombocytopenia, general disease activity, and active LN, but not with inactive renal disease. This is the first study investigating the clinical significance of this antibody in Turkish patients. Further studies are needed to clarify the pathogenesis of lupus nephritis. |
| format | Article |
| id | doaj-art-cf2bae3ee08a49f496ab57dfc8b0a0d6 |
| institution | DOAJ |
| issn | 1305-6441 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-cf2bae3ee08a49f496ab57dfc8b0a0d62025-08-20T02:58:39ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412024-10-0187431132010.26650/IUITFD.1464651123456ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITYSenem Tekeoğlu0https://orcid.org/0000-0001-5539-8755Duygu Temiz Karadağ1https://orcid.org/0000-0002-5891-2032Özlem Özdemir Işık2https://orcid.org/0000-0002-2985-3723Aylin Göçoğlu3https://orcid.org/0000-0002-8469-9247Fatma Ceyla Eraldemir4https://orcid.org/0000-0001-9410-8554Ayten Yazıcı5Ayşe Çefle6Haliç Üniversitesi, Istanbul, TurkiyeKocaeli Üniversitesi, Kocaeli, TürkiyeKocaeli Üniversitesi, Kocaeli, TürkiyeDokuz Eylül Üniversitesi, Izmir, TurkiyeKocaeli Üniversitesi, Kocaeli, TürkiyeKocaeli Üniversitesi, Kocaeli, TürkiyeKocaeli Üniversitesi, Kocaeli, TürkiyeObjective: Lupus nephritis (LN) is a detrimental consequence of systemic lupus erythematosus (SLE). The anti-C1q antibody was shown to be related to LN, or global disease activity, in various studies. Our purpose was to determine its prevalence and association with LN or disease activity in Turkish patients with SLE. Material and Method: We conducted a cross-sectional single-centre study to investigate the clinical and laboratory findings, disease activity, and anti-C1q levels in 150 patients with SLE. The anti-C1q antibody was analyzed using an enzyme-linked immunosorbent assay and compared with 150 healthy-control patients. Result: Lupus nephritis was present in 72 patients. The frequency of anti-C1q positivity was 17% (26/150) in patients with SLE and 3% (5/150) in control group (p<0.001). Patients with anti-C1q also had anti-Sm, direct Coombs’ test, and thrombocytopenia more commonly (p=0.001, p=0.007, p=0.009 respectively). Anti-C1q was positively correlated with proteinuria, haematuria, systemic lupus erythematosus disease activity index (SLEDAI) (p<0.001), anti-dsDNA (p=0.03), and negatively correlated with C3 (p<0.001) and C4 (p=0.015). Patients with active LN had higher anti-C1q (p=0.01) and anti-dsDNA (p<0.001) titres than inactive LN patients, although in multivariate logistic regression analysis, anti-C1q was not significant for LN history. It was significant for SLEDAI severity (p=0.036). Conclusion: Our study demonstrated a significant association of anti-C1q with SLE, proteinuria, haematuria, thrombocytopenia, general disease activity, and active LN, but not with inactive renal disease. This is the first study investigating the clinical significance of this antibody in Turkish patients. Further studies are needed to clarify the pathogenesis of lupus nephritis.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9A65D4D7883F480EA063A1F527EC022Aanti-c1qsystemic lupus erythematosuslupus nephritissystemic lupus erythematosus disease activity index |
| spellingShingle | Senem Tekeoğlu Duygu Temiz Karadağ Özlem Özdemir Işık Aylin Göçoğlu Fatma Ceyla Eraldemir Ayten Yazıcı Ayşe Çefle ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY İstanbul Tıp Fakültesi Dergisi anti-c1q systemic lupus erythematosus lupus nephritis systemic lupus erythematosus disease activity index |
| title | ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY |
| title_full | ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY |
| title_fullStr | ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY |
| title_full_unstemmed | ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY |
| title_short | ANTI-C1q IN SYSTEMIC LUPUS ERYTHEMATOSUS: RELATIONSHIP WITH CLINICAL MANIFESTATIONS AND DISEASE ACTIVITY |
| title_sort | anti c1q in systemic lupus erythematosus relationship with clinical manifestations and disease activity |
| topic | anti-c1q systemic lupus erythematosus lupus nephritis systemic lupus erythematosus disease activity index |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9A65D4D7883F480EA063A1F527EC022A |
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