Combining immunotherapy with radiotherapy for glioblastoma: recent advances and challenges
Glioblastoma (GBM) is an extremely aggressive brain tumor. Its standard treatment currently involves surgery followed by radiotherapy and temozolomide. However, recurrence is frequently unavoidable, and the effect of various treatments is not ideal due to numerous inherent obstacles. Immunotherapy h...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1523675/full |
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| author | Yuanyang Sun Yun Wang Shukun Mu Xiaofeng Wu Suchun Yu Zhongming Wang |
| author_facet | Yuanyang Sun Yun Wang Shukun Mu Xiaofeng Wu Suchun Yu Zhongming Wang |
| author_sort | Yuanyang Sun |
| collection | DOAJ |
| description | Glioblastoma (GBM) is an extremely aggressive brain tumor. Its standard treatment currently involves surgery followed by radiotherapy and temozolomide. However, recurrence is frequently unavoidable, and the effect of various treatments is not ideal due to numerous inherent obstacles. Immunotherapy has demonstrated promising prospects in the management of various cancers. Despite several preclinical studies have shown that immunotherapy may improve the survival in GBM mouse model, the results from completed clinical trials reveal that it brings only limited benefit for GBM patients to date. Interestingly, several studies have demonstrated that radiotherapy not only eliminates tumor cells by inducing DNA damages but also improves the effect of immunotherapy by modulating immune response. Combining immunotherapy with radiotherapy for GBM has been evaluated extensively. Herein, we present the immunotherapy applied in GBM and highlight the importance of tumor microenvironment in immunotherapy for GBM. Moreover, we review the preclinical and clinical data for applying immunotherapy combined with radiotherapy for GBM. Finally, we also discuss the challenges facing combined treatment of immunotherapy and radiotherapy for GBM and further research aspects in the discussion section. |
| format | Article |
| id | doaj-art-cf25eef384c84d989cfa01362f91c832 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-cf25eef384c84d989cfa01362f91c8322025-08-20T03:13:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.15236751523675Combining immunotherapy with radiotherapy for glioblastoma: recent advances and challengesYuanyang Sun0Yun Wang1Shukun Mu2Xiaofeng Wu3Suchun Yu4Zhongming Wang5School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Radiation Oncology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Radiation Oncology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Radiation Oncology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Pharmacy, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Radiation Oncology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaGlioblastoma (GBM) is an extremely aggressive brain tumor. Its standard treatment currently involves surgery followed by radiotherapy and temozolomide. However, recurrence is frequently unavoidable, and the effect of various treatments is not ideal due to numerous inherent obstacles. Immunotherapy has demonstrated promising prospects in the management of various cancers. Despite several preclinical studies have shown that immunotherapy may improve the survival in GBM mouse model, the results from completed clinical trials reveal that it brings only limited benefit for GBM patients to date. Interestingly, several studies have demonstrated that radiotherapy not only eliminates tumor cells by inducing DNA damages but also improves the effect of immunotherapy by modulating immune response. Combining immunotherapy with radiotherapy for GBM has been evaluated extensively. Herein, we present the immunotherapy applied in GBM and highlight the importance of tumor microenvironment in immunotherapy for GBM. Moreover, we review the preclinical and clinical data for applying immunotherapy combined with radiotherapy for GBM. Finally, we also discuss the challenges facing combined treatment of immunotherapy and radiotherapy for GBM and further research aspects in the discussion section.https://www.frontiersin.org/articles/10.3389/fonc.2025.1523675/fullglioblastomaimmunotherapyradiotherapytumor microenvironmentclinical trial |
| spellingShingle | Yuanyang Sun Yun Wang Shukun Mu Xiaofeng Wu Suchun Yu Zhongming Wang Combining immunotherapy with radiotherapy for glioblastoma: recent advances and challenges Frontiers in Oncology glioblastoma immunotherapy radiotherapy tumor microenvironment clinical trial |
| title | Combining immunotherapy with radiotherapy for glioblastoma: recent advances and challenges |
| title_full | Combining immunotherapy with radiotherapy for glioblastoma: recent advances and challenges |
| title_fullStr | Combining immunotherapy with radiotherapy for glioblastoma: recent advances and challenges |
| title_full_unstemmed | Combining immunotherapy with radiotherapy for glioblastoma: recent advances and challenges |
| title_short | Combining immunotherapy with radiotherapy for glioblastoma: recent advances and challenges |
| title_sort | combining immunotherapy with radiotherapy for glioblastoma recent advances and challenges |
| topic | glioblastoma immunotherapy radiotherapy tumor microenvironment clinical trial |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1523675/full |
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