The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that is caused by sepsis without direct brain injury or central nervous system infection and is manifested as anxiety-like behavior and cognitive dysfunction. The microbiota-gut-brain axis, on the other hand, is a bidirectional co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1587463/full |
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| author | Chen He Chen He Hui Shi Zhijie Yu Chunhan Ma Zhiqiang Jiao Jin Li Fei Yang Fei Yang |
| author_facet | Chen He Chen He Hui Shi Zhijie Yu Chunhan Ma Zhiqiang Jiao Jin Li Fei Yang Fei Yang |
| author_sort | Chen He |
| collection | DOAJ |
| description | Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that is caused by sepsis without direct brain injury or central nervous system infection and is manifested as anxiety-like behavior and cognitive dysfunction. The microbiota-gut-brain axis, on the other hand, is a bidirectional communication network between the gut and the brain that modulates host behavior and cognitive function in many ways and is of central importance in the preservation of general health and homeostasis. Given the functional roles attributed to the microbiota-gut-brain axis (MGBA), contemporary research is progressively focused on elucidating relationships between SAE and alterations in compositional and quantitative intestinal microbiota profiles. This review consolidates interdisciplinary insights from immunology, microbiology, neuroendocrine signaling, and neural pathophysiology to evaluate the mechanistic contribution of the MGBA to the relief of cognitive impairments in SAE. By unifying these perspectives, with the aim of preventing or enhancing SAE-related neurological dysfunction for the formulation of MGBA-targeted therapeutic strategies. |
| format | Article |
| id | doaj-art-cf1b819fcb154d958cf9f50902c406e9 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-cf1b819fcb154d958cf9f50902c406e92025-08-20T03:52:47ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-05-011510.3389/fcimb.2025.15874631587463The progress of the microbe-gut-brain axis in sepsis-associated encephalopathyChen He0Chen He1Hui Shi2Zhijie Yu3Chunhan Ma4Zhiqiang Jiao5Jin Li6Fei Yang7Fei Yang8Chifeng Clinical Medical College of Inner Mongolia Medical University, Hohhot, ChinaDepartment of Critical Care Medicine, Chifeng Municipal Hospital, Chifeng, ChinaDepartment of Critical Care Medicine, Chifeng Municipal Hospital, Chifeng, ChinaDepartment of Emergency Medicine, Chifeng Municipal Hospital, Chifeng, ChinaChifeng Clinical Medical College of Inner Mongolia Medical University, Hohhot, ChinaChifeng Clinical Medical College of Inner Mongolia Medical University, Hohhot, ChinaChifeng Clinical Medical College of Inner Mongolia Medical University, Hohhot, ChinaChifeng Clinical Medical College of Inner Mongolia Medical University, Hohhot, ChinaDepartment of Critical Care Medicine, Chifeng Municipal Hospital, Chifeng, ChinaSepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that is caused by sepsis without direct brain injury or central nervous system infection and is manifested as anxiety-like behavior and cognitive dysfunction. The microbiota-gut-brain axis, on the other hand, is a bidirectional communication network between the gut and the brain that modulates host behavior and cognitive function in many ways and is of central importance in the preservation of general health and homeostasis. Given the functional roles attributed to the microbiota-gut-brain axis (MGBA), contemporary research is progressively focused on elucidating relationships between SAE and alterations in compositional and quantitative intestinal microbiota profiles. This review consolidates interdisciplinary insights from immunology, microbiology, neuroendocrine signaling, and neural pathophysiology to evaluate the mechanistic contribution of the MGBA to the relief of cognitive impairments in SAE. By unifying these perspectives, with the aim of preventing or enhancing SAE-related neurological dysfunction for the formulation of MGBA-targeted therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1587463/fullsepsis-associated encephalopathymicrobe-gut-brain axisgut microbiotaneuroimmuneneuroendocrine |
| spellingShingle | Chen He Chen He Hui Shi Zhijie Yu Chunhan Ma Zhiqiang Jiao Jin Li Fei Yang Fei Yang The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy Frontiers in Cellular and Infection Microbiology sepsis-associated encephalopathy microbe-gut-brain axis gut microbiota neuroimmune neuroendocrine |
| title | The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy |
| title_full | The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy |
| title_fullStr | The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy |
| title_full_unstemmed | The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy |
| title_short | The progress of the microbe-gut-brain axis in sepsis-associated encephalopathy |
| title_sort | progress of the microbe gut brain axis in sepsis associated encephalopathy |
| topic | sepsis-associated encephalopathy microbe-gut-brain axis gut microbiota neuroimmune neuroendocrine |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1587463/full |
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